Biochemistry, International Adaptation - Donald Voet

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Auteur(s) : Donald Voet - Judith G. Voet

Editeur : John Wiley & Sons Inc

Langue : Anglais

Parution : 01/05/2021

Format : Moyen, de 350g à 1kg

Nombre de pages : 1488

Expédition : 3142

Dimensions : 27.4 x 21.8 x 5.6

ISBN : 1119770645

Résumé :

INTERNATIONAL ADAPTATION

Biochemistry

Biochemistry is a modern classic that is considered as the gold standard in Biochemistry textbooks. It presents the subject matter of biochemistry thoroughly and accurately with pedagogical excellence, thus providing a solid biochemical foundation. It also incorporates both classical and current research to illustrate the historical source of much of our biochemical knowledge. This International Adaptation of Biochemistry addresses the recent advancements in the field, particularly in the areas of structural biology and bioinformatics and their medical significance. It offers new and updated materials that highlight current developments in the field, especially in topics like Gene Expression, and Recombinant DNA Technology, Chemical and Biological Aspects of Hemoglobin, Citric Acid Cycle, Lipid Metabolism, and many more. It also focuses on strengthening the organization of the content and updating the end of chapter problems, thus presenting a brand-new experience to the reader.

This book and series is authorized for sale in Europe, Middle East, Africa, Asia, Australia and New Zealand only and may not be exported. The content is comprehensively adapted to international requirements and materially different from similar products for other markets including the authorized U.S. counterpart of this title.

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Biographie:
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Sommaire:

Guide to Media Resources xvi

Part I Introduction and background 1

Chapter 1 Life 3

1. The Origin of Life 3

2. Evolution of Cells 9

3. Biochemistry: A Prologue 18

4. Genetics: An Overview 23

Chapter 2 Aqueous Solutions and Bioenergetics 36

1. Properties of Water 37

2. Acids, Bases, and Buffers 40

3. First Law of Thermodynamics: Energy is Conserved 45

4. Second Law of Thermodynamics: The Universe Tends Toward Maximum Disorder 46

5. Chemical Equilibria 49

Appendix: Concentration Dependence of Free Energy 52

Part II Biomolecules 57

Chapter 3 Amino Acids 59

1. The Amino Acids of Proteins 59

2. Stereochemistry of Amino Acids 64

3. Chemical Properties of Amino Acids 69

4. Nonstandard Amino Acids 71

Chapter 4 Nucleic Acids, Gene Expression, and Recombinant DNA Technology 75

1. Nucleotides and Nucleic Acids 76

2. DNA Is the Carrier of Genetic Information 78

3. Double Helical DNA 81

4. Forces Stabilizing Nucleic Acid Structures 95

5. Supercoiled DNA 101

6. Gene Expression and Replication: An Overview 113

7. Molecular Cloning 122

Chapter 5 Techniques of Protein and Nucleic Acid Purification 150

1. Protein Isolation 150

2. Protein Solubility 154

3. Chromatographic Separations 156

4. Electrophoresis 167

5. Ultracentrifugation 173

6. Nucleic Acid Fractionation 178

Chapter 6 Covalent Structures of Proteins and Nucleic Acids 184

1. Primary Structure Determination of Proteins 185

2. Chemical Synthesis of Polypeptides 196

3. Nucleic Acid Sequencing 201

4. Chemical Synthesis of Oligonucleotides 210

5. Chemical Evolution 214

6. Bioinformatics: An Introduction 223

Chapter 7 Three-Dimensional Structures of Proteins 241

1. Secondary Structure 241

2. Fibrous Proteins 253

3. Globular Proteins 260

4. Protein Stability 280

5. Quaternary Structure 288

Appendix: Viewing Stereo Pictures 292

Chapter 8 Protein Folding, Dynamics, and Structural Evolution 300

1. Protein Folding: Theory and Experiment 300

2. Folding Accessory Proteins 312

3. Protein Structure Prediction and Design 324

4. Protein Dynamics 328

5. Conformational Diseases: Amyloid and Prions 331

6. Structural Evolution 338

Chapter 9 Chemical and Biological Aspects of Hemoglobin 346

1. Hemoglobin and Myoglobin Function 346

2. Structure and Mechanism 355

3. Abnormal Hemoglobins 364

4. Allosteric Regulation 371

Appendix: Derivations of Symmetry Model Equations 377

Chapter 10 Sugars and Polysaccharides 382

1. Monosaccharides 382

2. Polysaccharides 388

3. Glycoproteins 396

Chapter 11 Lipids and Membranes 409

1. Lipid Classification 409

2. Lipid Aggregates and their Properties 416

3. Biological Membranes 421

4. Membrane Assembly and Protein Targeting 440

5. Lipoproteins 468

Part III MECHANISMS OF ENZYME ACTION 485

Chapter 12 Enzyme Kinetics 487

1. Historical Perspective 488

2. Substrate Specificity 489

3. Coenzymes 492

4. Control of Enzymatic Activity 493

5. A Primer of Enzyme Nomenclature 498

6. Chemical Kinetics 498

7. Enzyme Kinetics 503

8. Inhibition 508

9. Effects of pH 512

10. Bisubstrate Reactions 513

Appendix: Derivations of Michaelis-Menten Equation Variants 516

Chapter 13 Enzymatic Catalysis and Drug Desig...