Brain Function and Dysfunction - Madhu, Anand

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Résumé :
Alzheimer's Disease is rapidly increasing in prevalence. This pandemic of the post-industrial age wreaks havoc on the elderly people (some as young as 40), particularly in the richer and more powerful nations. With only a few weak hypotheses, its cause is not understood; all proposed medicines have either failed clinical trials or proven ineffective. In this book, I lay out a new, relatively stronger and more broad-based theory of dementia causation, exploring beyond Matsuyama's 1989 theory that held pervasive Microtubule collapse to be a key characteristic of dementia. In brief: Psychological functions are carried out by neurocircuits containing myriads of Dopaminergic and Norepic systems; due to excessive electrical signalling in dopamine-heavy types of brains -- the signal conducting micro-tubules break down, causing the neuronal collapse which characterizes dementia. More the signalling volume, more the stress (either mechanical and/or thermal and/or chemical stress), which proves fatal in the end.