Fundamentals of Molecular Virology -

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Editeur : Wiley

Langue : Anglais

Parution : 01/06/2025

Format : Moyen, de 350g à 1kg

Nombre de pages : 672.0

ISBN : 9781119885863

Résumé :

Comprehensive coverage of major families of viruses, including human pathogens and viruses of organisms from bacteria to plants, with updated information on antiviral drugs, vaccines, antiviral immunity, and gene therapy

Fundamentals of Molecular Virology is a textbook designed for university students learning about viruses at the undergraduate or graduate levels. Chapters contributed by prominent virologists cover many of the major virus families. Each chapter is designed to tell a story about the viruses covered, including information on discovery, diseases and pathogenesis, virus structure, steps in replication, and interaction with cellular signaling pathways. This approach portrays the personality of each virus, helping students to learn the material and build up their knowledge of virology starting with smaller and simpler viruses and proceeding to more complex viruses.

Major importance is given to viruses that infect humans and cause disease, but coverage is broad, including viruses of bacteria, Archaea, algae, invertebrates, and plants. Information boxes highlight applications and research directions of particular significance. Chapters conclude with sections presenting fundamental concepts, review questions, and lists of key terms, which are defined in a glossary at the end of the book.

This 3rd edition of Fundamentals of Molecular Virology includes detailed information on the recent COVID-19 pandemic and mRNA vaccine technology, additional sections on pathogenic herpesviruses, and updates on recent outbreaks of Zika virus, Ebola virus and mpox diseases. New chapters describe hepatitis C virus, rhabdoviruses, viruses of invertebrates, oncolytic viruses, and virus-mediated gene therapy. All chapters, including those on innate and adaptive immune responses to virus infections, virus vaccines, and antiviral agents, were revised and updated.

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Biographie:

Christopher D. Richardson is Professor, Department of Microbiology & Immunology, Department of Pediatrics, Dalhousie University, Canada. Dr. Chris Richardson is a molecular virologist with 35 years of experience working with a variety of viruses. He earned his PhD at the University of British Columbia and did postdoctoral work at The Rockefeller University and the National Institutes of Health (Bethesda, USA). He previously held faculty positions at the National Research Council of Canada, McGill University, and the University of Toronto.

Nicholas H. Acheson is Emeritus Professor of Microbiology & Immunology at McGill University, Quebec, Canada. He earned his PhD from The Rockefeller University and was a postdoctoral fellow at the Swiss Institute for Experimental Cancer Research (Lausanne) and Institut Pasteur (Paris). He carried out research on Semliki Forest virus and mouse polyomavirus, and taught a virology course for advanced undergraduate students at McGill University....

Sommaire:

Section I: Introduction to Virology

1. Introduction to Virology 2
Nicholas H. Acheson, McGill University
Christopher D. Richardson, Dalhousie University

2. Virus Structure and Assembly 19
Stephen C. Harrison, Harvard University

3. Virus Classification: The World of Viruses 32
Nicholas H. Acheson, McGill University
Christopher D. Richardson, Dalhousie University

4. Virus Entry 47
Ari Helenius, Swiss Federal Institute of Technology, Zurich

Section II: Viruses of Bacteria and Archaea

5. Single-Stranded RNA Bacteriophages 60
Jan van Duin, University of Leiden
Karthik Chamakura, Armata Pharmaceuticals, Inc., Los Angeles
Ryland Young, Texas A&M University

6. Microviruses 74
Bentley A. Fane, University of Arizona
Aaron P. Roznowski, University of Arizona

7. Bacteriophage T7 84
William C. Summers, Yale University
Ian J. Molineux, University of Texas, Austin

8. Bacteriophage T4 94
Deborah M. Hinton, National Institutes of Health, Bethesda
Eric S. Miller, North Carolina State University

9. Bacteriophage Lambda 110
Michael Feiss, University of Iowa

10. Viruses of Archaea 123
David Prangishvili, Institut Pasteur, Paris Mart Krupovic, Institut Pasteur, Paris

Section III: Positive-Strand RNA Animal Viruses

11. Picornaviruses 140
Bert L. Semler, University of California, Irvine

12. Flaviviruses 152
Richard Kuhn, Purdue University
Shelton Bradrick, Trudeau Institute, New York

13. Hepaciviruses 164
John Lok Man Law, Memorial University of Newfoundland
Michael Houghton, University of Alberta

14. Togaviruses and Rubella Virus 178
Anil Kumar, University of Saskatchewan
Milton Schlesinger, Washington University, St. Louis
Sondra Schlesinger, Washington University, St. Louis
Tom C. Hobman, University of Alberta

15. Coronaviruses 192
Marc Desforges, Ste. Justine Hospital, Universit? de Montr?al
Pierre Talbot, Institut Armand-Frappier
Mark Denison, Vanderbilt University

Section IV: Negative-Strand and Double-Stranded RNA Animal Viruses

16. Paramyxoviruses and Pneumoviruses 210
Nicholas H. Acheson, McGill University
Daniel Kolakofsky, University of Geneva
Laurent Roux, University of Geneva
Christopher D. Richardson, Dalhousie University

17. Rhabdoviruses 226
Valery Grdzelishvili, University of North Carolina, Charlotte
Cassandra A. Catacalos, University of North Carolina, Charlotte

18. Filoviruses 237
Heinz Feldmann, Rocky Mountain Laboratories, Montana
Hans-Dieter Klenk, University of Marburg
Nicholas H. Acheson, McGill University
Angela Rasmussen, University of Saskatchewan

19. Bunyaviruses 251
Richard M. Elliott, University of Glasgow
Lev Levanov, University of Helsinki
Alexander Plyusnin, University of Helsinki

20. Influenza Viruses 262
Dalius J. Briedis, McGill University
Alyson Kelvin, University of Calgary

21. Reoviruses 278
Kristen M. Ogden, Vanderbilt University
Terence S. Dermody, University of Pittsburgh School of Medicine

Section V: Small DNA Animal Viruses

22. Parvoviruses 292
Peter Beard, ?cole Polytechnique F?d?rale de Lausanne
Sarah Wootton, University of Guelph

23. Polyomaviruses 302
Nicholas H. Acheson, McGill University
James A. DeCaprio, Dana-Farber Cancer Institute, Harvard University

24. Papillomaviruses 318
Greg Matlas...