Multivariate Data Integration Using R - Lê Cao, Kim-Anh

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Auteur(s) : Lê Cao, Kim-Anh - Welham, Zoe Marie

Editeur : Chapman And Hall/Crc

Langue : Anglais

Parution : 01/11/2021

Format : Moyen, de 350g à 1kg

Nombre de pages : 332.0

Expédition : 789

Dimensions : 25.4 x 17.8 x 2.2

ISBN : 9780367460945

Résumé :

This book provides an overview of statistical and dimension reduction methods for high-throughput biological data, with a specific focus on data integration. It starts with some biological background, key concepts underlying the multivariate methods, and then covers an array of methods implemented using the mixOmics package in R.

Biographie:

Dr Kim-Anh L? Cao develops novel methods, software and tools to interpret big biological data and answer research questions efficiently. She is committed to statistical education to instill best analytical practice and has taught numerous statistical workshops for biologists and leads collaborative projects in medicine, fundamental biology or microbiology disciplines. Dr Kim-Anh L? Cao has a mathematical engineering background and graduated with a PhD in Statistics from the Universit? de Toulouse, France. She then moved to Australia first as a biostatistician consultant at QFAB Bioinformatics, then as a research group leader at the biomedical University of Queensland Diamantina Institute. She currently is Associate Professor in Statistical Genomics at the University of Melbourne. In 2019, Kim-Anh received the Australian Academy of Science's Moran Medal for her contributions to Applied Statistics in multidisciplinary collaborations. She has been part of leadership program for women in STEMM, including the international Homeward Bound which culminated in a trip to Antarctica, and Superstars of STEM from Science Technology Australia.

Zoe Welham completed a BSc in molecular biology and during this time developed a keen interest in the analysis of big data. She completed a Masters of Bioinformatics with a focus on the statistical integration of different omics data in bowel cancer. She is currently a PhD candidate at the Kolling Institute in Sydney where she is furthering her research into bowel cancer with a focus on integrating microbiome data with other omics to characterise early bowel polyps. Her research interests include bioinformatics and biostatistics for many areas of biology and disseminating that information to the general public through reader-friendly writing.

Sommaire:

I Modern biology and multivariate analysis

1. Multi-omics and biological systems
2. The cycle of analysis
3. Key multivariate concepts and dimension reduction in mixOmics
4. Choose the right method for the right question in mixOmics

II mixOmics under the hood

5. Projection to Latent Structures
6. Visualisation for data integration
7. Performance assessment in multivariate analyses

III mixOmics in action

8. mixOmics: get started
9. Principal Component Analysis (PCA)
10. 10 Projection to Latent Structure (PLS)
11. Canonical Correlation Analysis (CCA)
12. PLS - Discriminant Analysis (PLS-DA)
13. N ? data integration
14. P ? data integration
15. Glossary of Terms