Cell Biology - Andrea Townsend-Nicholson

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Auteur(s) : Andrea Townsend-Nicholson - Elizabeth A. Shephard - Greg FitzHarris - Jeremy S. Hyams - Sandip Patel - Stephen R. Bolsover

Editeur : John Wiley And Sons Ltd

Langue : Anglais

Parution : 01/03/2022

Format : Moyen, de 350g à 1kg

Nombre de pages : 336

Expédition : 910

Dimensions : 21.6 x 35.9 x 23.0

ISBN : 9781119757764

Résumé :

An accessible and straightforward intro to cell biology

In the newly revised Fourth Edition of Cell Biology: A Short Course, a distinguished team of researchers delivers a concise and accessible introduction to modern cell biology, integrating knowledge from genetics, molecular biology, biochemistry, physiology, and microscopy. The book places a strong emphasis on drawing connections between basic science and medicine.

Telling the story of cells as the units of life in a colorful and student-friendly manner, Cell Biology: A Short Course takes an essentials only approach. It conveys critical points without overburdening the reader with extraneous or secondary information. Clear diagrams and examples from current research accompany special boxed sections that focus on the importance of cell biology in medicine and industry. A new feature, BrainBoxes describes some of the key people who created the current understanding of Cell Biology.

The book has been thoroughly revised and updated since the last edition and includes:

• Thorough introduction to cells and tissues, membranes, organelles, and the structure of DNA and genetic code
• Explorations of DNA as a data storage medium, transcription and the control of gene expression, and recombinant DNA and genetic engineering
• Discussion of the manufacture of proteins, protein structure, and intracellular protein trafficking
• Description of ions and voltages, intracellular and extracellular signaling
• Introduction to the cytoskeleton and cell movement
• Discussion of cell division and apoptosis

Perfect for undergraduate students seeking an accessible, one-stop reference on cell biology, Cell Biology: A Short Course is also an ideal reference for pre-med students.

...

Biographie:

Preface, xi

Acknowledgments, xiii

About the companion website, xv

Section 1: The Structure of the Cell, 1

1 A Look at Cells and Tissues, 3

Only Two Types of Cell, 3

Cell Division, 4

Viruses, 4

Origin of Eukaryotic Cells, 6

Cell Specialization in Animals, 8

Stem Cells and Tissue Replacement, 10

The Cell Wall, 11

Microscopes Reveal Cell Structure, 11

The Modern Light Microscope, 11

The Transmission Electron Microscope, 12

The Scanning Electron Microscope, 14

Fluorescence Microscopy, 14

Increasing the Resolution of Fluorescence Microscopes, 15

Fluorescent Proteins, 15

2 Membranes and Organelles, 21

Basic Properties of Cell Membranes, 21

Organelles Bounded by Double-Membrane Envelopes, 22

The Nucleus, 22

Mitochondria, 24

Organelles Bounded by Single Membranes, 24

Peroxisomes, 25

Endoplasmic Reticulum, 25

Golgi Apparatus, 25

Lysosomes, 25

The Connected Cell, 26

Organelle Junctions, 26

Cell Junctions, 26

Section 2: The Molecular Biology Of The Cell, 33

3 DNA Structure And The Genetic Code, 35

The Structure of DNA, 35

The DNA Molecule Is a Double Helix, 37

Hydrogen Bonds Form Between Base Pairs, 37

DNA Strands Are Antiparallel, 37

The Two DNA Strands Are Complementary, 39

DNA as the Genetic Material, 39

Packaging of DNA Molecules into Chromosomes, 39

Eukaryotic Chromosomes and Chromatin Structure, 39

Prokaryotic Chromosomes, 40

Plasmids, 41

Viruses, 42

The Genetic Code, 42

Amino Acids and Proteins, 42

Reading the Genetic Code, 42

Amino Acid Names Are Abbreviated, 44

The Code Is Degenerate but Unambiguous, 44

Start and Stop Codons and the Reading Frame, 45

The Code Is Nearly Universal, 45

Missense Mutations, 46

4 DNA As A Data Storage Medium, 51

DNA Replication, 51

The DNA Replication Fork, 51

Proteins Open up the DNA Double Helix During Replication, 51

DnaA Protein, 52

DnaB and DnaC Proteins, 52

Single-Stranded DNA-Binding Proteins, 52

Biochemistry of DNA Replication, 52

DNA Synthesis Requires an RNA Primer, 55

RNA Primers Are Removed, 55

The Self-Correcting DNA Polymerase, 55

Mismatch Repair Backs Up the Proofreading Mechanism, 55

DNA Repair after Replication, 56

Spontaneous and Chemically Induced Base Changes, 56

Repair Processes, 57

Gene Structure and Organization in Eukaryotes, 59

Introns and Exons - Additional Complexity in Eukaryotic Genes, 59

The Major Classes of Eukaryotic DNA, 60

Gene Nomenclature, 61

5 Transcription and the Control of Gene Expression, 67

Structure of RNA, 67

RNA Polymerase, 67

Gene Notation, 68

Bacterial RNA Synthesis, 69

Control of Bacterial Gene Expression, 71

Lac, an Inducible Operon, 71

Trp, a Repressible Operon, 74

Eukaryotic RNA Synthesis, 75

Messenger RNA Processing in Eukaryotes, 76

Control of Eukaryotic Gene Expression, 77

Glucocorticoids Cross the Plasma Membrane to Activate Transcription, 79

Noncoding RNAs and the Control of Eukaryotic Gene Expression, 80

Micro RNAs, 80

Long Noncoding RNAs, 81

Circular RNAs, 81

6 Manufacturing Protein, 85

Attachment of an Amino Acid to Its tRNA, 85

Transfer RNA, the Anticodon, and Wobble, 85

The Ribosome, 89

Bacterial Protein Synthesis, 89

Ribosome-Binding Site, 89

Sommaire:

Stephen Bolsover is Professor Emeritus of Cell Physiology at University College London (UCL). His research focussed on the role of calcium as an intracellular messenger.

Andrea Townsend-Nicholson is Professor of Biochemistry & Molecular Biology at UCL. She is particularly interested in integrating high performance computing and experimental methodologies for the study of G protein-coupled receptors. She served as the Head of Teaching for Molecular Biosciences at UCL from 2010-2019.

Greg FitzHarris was previously a student and then lecturer at UCL, and is now Professor and Head of the Department of Pathology and Cell Biology at Universit? de Montr?al.

Elizabeth Shephard is a Professorial Research Associate at UCL. She has a particular interest in rare genetic disorders and is a scientific advisor for the patient advocacy group, MEBO Research. She has served terms as Vice-Dean Education, Faculty Life Sciences, UCL.

Jeremy Hyams was Professor of Cell Biology at UCL. He left in 2003 to become head of the Institute of Molecular Biosciences at Massey University, New Zealand. He retired in 2008.

Sandip Patel is Professor of Cell Signalling and Deputy Head of the Department of Cell and Developmental Biology at UCL. He has been teaching cell biology to variety of students for more years than he cares to remember but finds time to run a research lab....