Modern Adaptive Randomized Clinical Trials -

. .

Résumé :
..

Biographie:
Oleksandr Sverdlov

Sommaire:

An Overview of Adaptive Randomization Designs in Clinical Trials. Efron's Biased Coin Design Revisited: Statistical Properties, Randomization-Based Inference, and Sequential Monitoring. Adaptive Biased Coins: Achieving Better Balance without Compromising Randomness. Brick Tunnel and Wide Brick Tunnel Randomization for Studies with Unequal Allocation. Development of Novel Covariate-Adaptive Randomization Designs. Optimal Model-Based Covariate-Adaptive Randomization Designs. Statistical Inference Following Covariate-Adaptive Randomisation: Recent Advances. Covariate-Adaptive Randomization with Unequal Allocation. Optimal Allocation Designs for a Multi-Arm Multi-Objective Clinical Trial. Response-Adaptive Randomization: An Overview of Designs and Asymptotic Theory. Statistical Inference Following Response-Adaptive Randomization. Sample Size Re-Estimation in Adaptively Randomized Clinical Trials with Missing Data. Some Caveats for Outcome Adaptive Randomization in Clinical Trials. Efficient and Ethical Adaptive Clinical Trial Designs to Detect Treatment-Covariate Interaction. Longitudinal Covariate-Adjusted Response-Adaptive Randomization: Impact of Missing Data. Targeted Covariate-Adjusted Response-Adaptive LASSO-Based Randomized Controlled Trials. Covariate-Balanced Bayesian Adaptive Randomization: Achieving Tradeoff Between Inferential and Ethical Goals in Small and Moderate Size Trials. Multi-Arm Multi-Stage Designs for Clinical Trials with Treatment Selection. Sequential Elimination in Multi-Arm Selection Trials. Accounting for Parameter Uncertainty in Two-Stage Designs for Phase II Dose-Response Studies. A Single Pivotal Adaptive Trial in Infants with Proliferating Hemangioma: Rationale, Design Challenges, Experience, and Recommendations. Practical Implementation of Dose-Response Adaptive Trials. Statistical Monitoring of Data in Response-Adaptive Randomized Clinical Trials.