Materials for Biomedical Engineering - Rahaman, Mohamed N.

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Résumé :
MATERIALS FOR BIOMEDICAL ENGINEERING

A comprehensive yet accessible introductory textbook designed for one-semester courses in biomaterials

Biomaterials are used throughout the biomedical industry in a range of applications, from cardiovascular devices and medical and dental implants to regenerative medicine, tissue engineering, drug delivery, and cancer treatment. Materials for Biomedical Engineering: Fundamentals and Applications provides an up-to-date introduction to biomaterials, their interaction with cells and tissues, and their use in both conventional and emerging areas of biomedicine.

Requiring no previous background in the subject, this student-friendly textbook covers the basic concepts and principles of materials science, the classes of materials used as biomaterials, the degradation of biomaterials in the biological environment, biocompatibility phenomena, and the major applications of biomaterials in medicine and dentistry. Throughout the text, easy-to-digest chapters address key topics such as the atomic structure, bonding, and properties of biomaterials, natural and synthetic polymers, immune responses to biomaterials, implant-associated infections, biomaterials in hard and soft tissue repair, tissue engineering and drug delivery, and more.

• Offers accessible chapters with clear explanatory text, tables and figures, and high-quality illustrations
• Describes how the fundamentals of biomaterials are applied in a variety of biomedical applications
• Features a thorough overview of the history, properties, and applications of biomaterials
• Includes numerous homework, review, and examination problems, full references, and further reading suggestions

Materials for Biomedical Engineering: Fundamentals and Applications is an excellent textbook for advanced undergraduate and graduate students in biomedical materials science courses, and a valuable resource for medical and dental students as well as students with science and engineering backgrounds with interest in biomaterials....

Biographie:

Mohamed N. Rahaman, Professor Emeritus of Materials Science and Engineering, Missouri University of Science and Technology, USA. Dr. Rahaman is a Fellow of the American Ceramic Society, the author of five textbooks, the author and co-author of over 280 reviewed journal articles and conference proceedings, and the co-inventor on three US patents in the area of medical devices.

Roger F. Brown, Professor Emeritus of Biological Sciences, Missouri University of Science and Technology, USA. Dr Brown is the author and co-author of over 60 reviewed journal articles and conference proceedings, and is a co-inventor on one US patent pertaining to the use of bioactive borate glass microfibers for soft tissue repair....

Sommaire:

Preface xix

About the Companion Website xxi

Part I General Introduction 1

1 Biomaterials - An Introductory Overview 3

1.1 Introduction 3

1.2 Definition and Meaning of Common Terms 3

1.3 Biomaterials Design and Selection 8

1.3.1 Evolving Trend in Biomaterials Design 8

1.3.2 Factors in Biomaterials Design and Selection 9

1.4 Properties of Materials 11

1.4.1 Intrinsic Properties of Metals 11

1.4.2 Intrinsic Properties of Ceramics 11

1.4.3 Intrinsic Properties of Polymers 12

1.4.4 Properties of Composites 12

1.4.5 Representation of Properties 13

1.5 Case Study in Materials Design and Selection: The Hip Implant 13

1.6 Brief History of the Evolution of Biomaterials 17

1.7 Biomaterials - An Interdisciplinary Field 19

1.8 Concluding Remarks 19

Part II Materials Science of Biomaterials 21

2 Atomic Structure and Bonding 23

2.1 Introduction 23

2.2 Interatomic Forces and Bonding Energies 23

2.3 Types of Bonds between Atoms and Molecules 26

2.4 Primary Bonds 27

2.4.1 Ionic Bonding 29

2.4.2 Covalent Bonding 30

2.4.3 Metallic Bonding 33

2.5 Secondary Bonds 34

2.5.1 Van der Waals Bonding 34

2.5.2 Hydrogen Bonding 35

2.6 Atomic Bonding and Structure in Proteins 36

2.6.1 Primary Structure 36

2.6.2 Secondary Structure 37

2.6.3 Tertiary Structure 38

2.6.4 Quaternary Structure 43

2.7 Concluding Remarks 44

3 Structure of Solids 47

3.1 Introduction 47

3.2 Packing of Atoms in Crystals 47

3.2.1 Unit Cells and Crystal Systems 49

3.3 Structure of Solids Used as Biomaterials 51

3.3.1 Crystal Structure of Metals 51

3.3.2 Crystal Structure of Ceramics 52

3.3.3 Structure of Inorganic Glasses 54

3.3.4 Structure of Carbon Materials 55

3.3.5 Structure of Polymers 57

3.4 Defects in Crystalline Solids 58

3.4.1 Point Defects 59

3.4.2 Line Defects: Dislocations 59

3.4.3 Planar Defects: Surfaces and Grain Boundaries 62

3.5 Microstructure of Biomaterials 62

3.5.1 Microstructure of Dense Biomaterials 63

3.5.2 Microstructure of Porous Biomaterials 64

3.6 Special Topic: Lattice Planes and Directions 65

3.7 Concluding Remarks 67

4 Bulk Properties of Materials 69

4.1 Introduction 69

4.2 Mechanical Properties of Materials 69

4.2.1 Mechanical Stress and Strain 70

4.2.2 Elastic Modulus 72

4.2.3 Mechanical Response of Materials 74

4.2.4 Stress-Strain Behavior of Metals, Ceramics, and Polymers 78

4.2.5 Fracture of Materials 79

4.2.6 Toughness and Fracture Toughness 82

4.2.7 Fatigue 82

4.2.8 Hardness 83

4.3 Effect of Microstructure on Mechanical Properties 84

4.3.1 Effect of Porosity 84

4.3.2 Effect of Grain Size 85

4.4 Designing with Ductile and Brittle Materials 85

4.4.1 Designing with Metals 85

4.4.2 Designing with Ceramics 85

4.4.3 Designing with Polymers 87

4.5 Electrical Properties 87

4.5.1 Electrical Conductivity of Materials 87

4.5.2 Electrical Conductivity of Conducting Polymers 88

4.6 Magnetic Properties 88

4.6.1 Origins of Magnetic Response in Materials 88

4.6.2 Meaning and Definition of Relevant Magnetic Properties 89

4.6.3 Diamagnetic and Paramagnetic Materials 89

4.6.4 Ferromagnetic Materials 90

4.6.5 Ferrimagnetic Materials 91

4.6.6 Magnetization Curves and Hysteresis 91

4.6.7 Hyperthermia Treatment of T...