Human Blood Plasma Proteins - Schaller, Johann

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Résumé :

Preface xi

1 Introduction 1

References 3

Part I 5

2 Blood Components 7

2.1 Introduction 7

2.2 Short History 7

2.3 Blood Components 8

2.3.1 Blood cells 8

2.3.2 Blood plasma 12

2.3.3 The blood group system 13

References 15

Data Sheet 16

3 Blood Plasma Proteins 17

3.1 Introduction 17

3.2 Short History 17

3.3 Classification of Blood Plasma Proteins 17

References 20

Part II 21

4 Domains, Motifs and Repeats 23

4.1 Introduction 23

4.2 The Epidermal Growth Factor (EGF)-Like Domain 24

4.3 The Kringle Domain 26

4.4 The g-Carboxyglutamic Acid-Rich (Gla) Domain 27

4.5 The PAN/Apple Domain 28

4.6 The Sushi/CCP/SCR Domain 30

4.7 The Fibronectin Type I, the Fibronectin Type II Collagen-Binding and the Fibronectin Type III Domains 31

4.8 The Coagulation Factors 5/8 Type C Domain (FA58C) 32

4.9 The Thrombospondin Type I Repeat (TSP1) 34

4.10 The VWFA, VWFC and VWFD Domains 35

4.11 The Cystatin-Like Domain 36

4.12 The LDL-Receptor Class A (LDLRA) and Class B (LDLRB) Domains 36

4.13 The C-Terminal Cystine Knot (CTCK) Structure 38

4.14 The Anaphylatoxin Domain 40

4.15 The CUB Domain 40

4.16 The NTR Domain 41

4.17 The C-Type Lectin (CTL) Domain 42

4.18 The Ig-Like Domain 43

References 44

5 Protein Families 47

5.1 Introduction 47

5.2 Serine Proteases: The Trypsin Family 47

5.3 Serine Protease Inhibitors (Serpins) 48

5.4 The a2-Macroglobulin Family 50

5.5 The Serum Albumin Family 52

5.6 The Pancreatic Trypsin Inhibitor (Kunitz) Family Signature 52

5.7 The Kazal Serine Protease Inhibitors Family Signature 53

5.8 The Multicopper Oxidase Family 54

5.9 The Lipocalin Family 54

5.10 The Globin Family 55

5.11 The Glucagon/Gastric Inhibitory Polypeptide (GIP)/Secretin/ Vasoactive Intestinal Peptide (VIP) Family 56

5.12 The Glycoprotein Hormone Family 58

5.13 Membrane Attack Complex Components/Perforin Signature (The Complement C6/C7/C8/C9 Family) 59

5.14 The Lipase Family 60

5.15 Hormone Families and Signatures 61

5.15.1 The erythropoietin/thrombopoietin signature 61

5.15.2 The corticotropin-releasing factor family 61

5.15.3 The gonadotropin-releasing hormone signature 62

5.15.4 The calcitonin/CGRP/IAPP family 62

5.15.5 The gastrin/cholecystokinin family 62

5.15.6 The insulin family 62

5.16 Growth Factor Families 64

5.16.1 The platelet-derived growth factor family 64

5.16.2 The transforming growth factor-b family 64

5.17 Cytokine Families 65

5.17.1 The tumor necrosis factor family 65

5.17.2 The interferon a, b and d family 66

5.18 Interleukin Families and Signatures 66

5.18.1 The interleukin-1 signature 66

5.18.2 The interleukin-2 signature 67

5.18.3 The interleukin-4/-13 signature 68

5.18.4 The interleukin-6/granulocyte colony-stimulating factor/myelomonocytic growth factor family 68

5.18.5 The interleukin-7 and -9 signature 69

5.18.6 Interleukin-10 family 69

5.19 The Small Cytokine (Intercrine/Chemokine) Family and Signature 70

References 72

6 Posttranslational Modifications 75

6.1 Introduction 75

6.2 Databases for Posttranslational Modifications (PTMs) 75

6.3 Disulfide Bridges 75

6.4 Glycosylation 77

6.5 Phosphorylation 79

6.5.1 Ser/Thr phosphorylation sites 80

6.5.2 Tyr phosphorylation site 81

6.6 Hydroxylation 81

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