Cut-and-Paste Genetics - Sarkar, Sahotra

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Résumé :
Preface / 1. Inborn Errors of Metabolism / 2. Genetic Hygiene and Its Aftermath / 3. Molecular Diseases, Elusive Treatments / 4. Dreams of Gene Therapy / 5. The Human Genome Project / 6. The CRISPR Revolution / 7. Inevitable Eugenics? / 8. The Elimination of Genetic Diseases / 9. Designer Baby Delusions / 10. The Future of the Human Genome...

Biographie:
Sahotra Sarkar is a Professor in the Departments of Philosophy and Integrative Biology at the University of Texas, Austin. He came to Texas after teaching at Boston and McGill Universities and holding fellowships at MIT and the Max Planck Institute. A specialist in the history and philosophy of science, he has particular interests in both philosophy of biology and physics....

Sommaire:

Preface
1.Breeding a Perfect Society
Beginnings: Davenport and eugenics in the United States * IQ and involuntary sterilization * Genetics against eugenics * Exporting sterilization * The Watson scandal * Davenport's dreams today
2.Molecular Diseases, Elusive Treatments
The molecularization of biology * Molecular diseases * But no molecular medicine
*Dreams of editing genes * Followed by stunning failure * Recombinant DNA made no difference * Gene editing BC
3.What Good Was the Human Genome Project?
The sequence revealed * Common diseases and common variants * Medical irrelevance of the sequence * Critiques of the HGP, past and present * Evolution and architecture of the genome * Evolutionary contingency
4.The CRISPR Revolution
The CRISPR structure emerges * Its function is decoded * The mechanism of immunity * Onward to gene editing * The delivery problem * Ubiquitous CRISPR
5.Inevitable Eugenics?
Eugenics in the news * What is eugenics? * Defining eugenics * A working definition * Inescapable eugenics? * Matters of ethics
6.Eliminating Genetic Diseases
The long reach of Huntington's disease * The He Jiankui affair * The ethics of human germ-line intervention * The limits of current science * Gene specificity and Lenin's brain * A policy proposal * Proceed with caution * Liberal and moderate eugenics
7.Designer Baby Delusions
Why not genetic enhancement? * The normal and the enhanced * Liberal eugen- ics and genetic enhancement * Rationality of genetic enhancement * Planned human obsolescence * Where is the science? The case of intelligence * Genomics and IQ * What about physical traits * Genetic reductionism * Contextual developmental construction * What is perfection?
8.A CRISPR Future
Editing the human germ-line * Gene drives * The ethics of promoting extinction
*Biosecurity * CRISPR without the hype