Molecular Infection Biology: Interactions Between Microorganisms and Cells - Hacker

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Résumé :
This comprehensive volume focuses on molecular methods and principles of prokaryotic and eukaryotic pathogens. The authors present the molecular and cellular aspects by focusing on the interactions between pathogenic microorganisms and their hosts. The publication begins with an overview of the most important and dangerous causative agents of infectious diseases. Next are discussions of how microbial weapons, pathogenicity factors, protein secretion machines, and surface variation systems work, presenting the molecular and genetic methods that are used by scientists for their discovery and analysis. Furthermore, infectious diseases are discussed in light of the newly formed research areas of evolutionary and cellular microbiology and genomics. Future aspects on diagnostic techniques, therapy, and vaccine development are also presented.

Sommaire:
Foreword (J. Kaper). Acknowledgments. Contributors. Introduction (J. Hacker & J. Heesemann). Medically Significant Pathogens (J. Heesemann & J. Hacker). Host Defenses Against Microorganisms--Nonspecific Defenses (J. Heesemann). The Adaptive Immune System (J. Heesemann). Symbiosis, Infection, and Pathogenicity (U. Hentschel & J. Hacker). Offensive Pathogenicity Factors (J. Hacker). Defensive Pathogenicity Factors (R. Haas & M. Hensel). Nonspecific Pathogenicity Factors (J. Hacker). Protein Secretion Systems (J. Heesemann & T. ÖlschlÄger). Microbial Surface Variation and Pathogenicity (J. MorschhÄuser). Regulation of Virulence-Associated Genes (J. MorschhÄuser). Infection Ecology (J. Hacker). Parallels Between Plant and Human Pathogens (J. Hacker). Evolutionary Infection Biology (J. Hacker). Cellular Microbiology (T. ÖlschlÄger & J. Heesemann). In Vivo Expression of Pathogenicity (M. Hensel). Genomics, Transcriptomics, and Proteomics (J. Reidl & J. Hacker). Molecular Diagnosis and Epidemiology (J. Hacker & J. Heesemann). Therapeutic Problems with Infectious Diseases (W. Ziebuhr). The Development of Vaccines (J. Heesemann). Infection Models (J. Hacker). Future Developments (J. Hacker & J. Heesemann). Methods of Molecular Infection Biology (J. Hacker). Appendix. Index.