Polymeric Micelle Nanocarriers - Ronak Vakil
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Avis sur Polymeric Micelle Nanocarriers de Ronak Vakil Format Broché - Livre Physique - Chimie
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Présentation Polymeric Micelle Nanocarriers de Ronak Vakil Format Broché
- Livre Physique - Chimie
Résumé :
Revision with unchanged content. The potential of polymeric micelles formed from biocompatible or generally regarded as safe (GRAS) materials as sustained release nanocarriers for amphotericin B has been evaluated in this dissertation as further development can proceed without an explicit concern for biocompatibility which may slow progress of particulate carriers prepared from novel synthetic polymers. PEG-phospholipid (PEG-DSPE) micelles clearly prevented AmB induced toxicity pointing to stable drug incorporation, in vitro. However, drug release and absorption kinetics revealed that AmB was rapidly dissociated from PEG-DSPE micelles in serum albumin, a likely situation in vivo. Cholesterol co-incorporation influenced properties of PEG-DSPE micelles and slowed AmB release in serum albumin raising promise as long circulating carriers for AmB delivery. Further, AmB in PEG-DSPE micelles was stable in saline when combined with 5-fluorocytosine and solubilized rapamycin. Hence, PEG-DSPE micelles represent an interesting alternative to deoxycholate-AmB, particularly in combination therapy involving AmB with optional continuous infusion or sodium supplementation....
Biographie:
The author received his Ph.D in Pharmaceutical Sciences fromthe University of Wisconsin - Madison in 2006 andis currently working at Novartis PharmaceuticalsCorporation at East Hanover, New Jersey....