Major Histocompatibility Complex -

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Résumé :
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Sommaire:
Origin of the MHC.- Jaws and AIS.- The MHC paralogous group: listing of members and a brief overview.- The MHC ? Big-Bang ? : duplication and exon shuffling during chordate evolution. A hypothetico-deductive approach.- Relationships among the genes encoding MHC molecules and the specific antigen receptors.- Conserved linkage among sea urchin homologs of genes encoded in the vertebrate MHC region.- Genome organization of the MHC.- Physical mapping of the class I regions of the rat major histocompatibility complex.- MHC gene organization of the bony fish, medaka.- Polymorphic olfactory receptor genes and HLA loci constitute extended haplotypes.- Distribution of polypurine/polypyrimidine tract sequences in the human MHC region and their possible functions.- Potential for paralogous mapping to simplify the genetics of diseases and functions associated with MHC haplotypes.- Transposable elements and the metamerismatic evolution of the HLA class I region.- Polymorphism in the HLA class I region.- Nucleotide diversity within the human major histocompatibility complex: function of hitchhiking effect, duplications, indels and recombination.- Function and evolutionary dynamics of MHC genes.- Proteasomes and MHC class I-peptide generation.- Comparative aspects of the MHC class I-related MR1, CD1D, and MIC genes in primates.- Rat TL and CD1.- Are chicken Rfp-Y class I genes classical or non-classical?.- Xenopus class I proteins.- Two MHC class II A loci in the channel catfish.- The evolution of MHC class I genes in cattle.- Evidence for four functional DQA loci in cattle with distinct distributions amongst European and African populations.- Natural killer gene complex.- The NKC and regulation of natural killer cell-mediated immunity.- MHC-pathogen coevolution.- Manipulation of MHC-encoded proteins by cytomegaloviruses.- An animal model for understanding the immunogenetics of AIDS virus infection.- MHC polymorphism.- Evolution of HLA-DRB loci, DRB1 lineages, and alleles: analyses of intron-1 and -2 sequences.- The non-coding regions of HLA-DRB uncover inter-lineage recombinations as a mechanism of HLA diversification.- Conversion or convergence? Introns of primate DRB genes tell the true story.- Intron 1 sequence analysis of the MHC-DRB1, 3, 4, 5, and 6 genes in five non-human primate species.- Evolution of Catarrhini DPB1 exon 2 under intragenic recombination.- The effect of mutation, recombination and selection on HLA non-coding sequences.- HLA-DQ haplotypes in 15 different populations.- HLA class I and class II loci in Pacific/Asian populations.- HLA class I alleles in Australian aborigines and their peptide binding profiles.- An evolutionary overview of the MHC-G polymorphism: clues to the unknown function(s).- MIC-A polymorphism and a MIC-A-MIC-B null haplotype with ~ 100-kb deletion.- Repertoire forecast of MHC class I binding peptides with peptide libraries.- Sequence conditions for gene conversion of mouse MHC genes.- Mhc class II genes of Darwin's Finches: divergence by point mutations and reciprocal recombination.- Contrasting patterns of MHC and microsatellite diversity in social and solitary tuco-tucos (Rodentia: Ctenomyidae).