Medicinal Chemistry - Gareth Thomas
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Présentation Medicinal Chemistry de Gareth Thomas Format Relié
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Résumé : Medicinal Chemistry, Second Edition provides a comprehensive, balanced introduction to this evolving, multi-disciplinary subject. The book carefully explains fundamental principles, assuming little in the way of prior knowledge. It opens with a broad overview of medicinal chemistry followed by chapters that cover the principal methods used in drug design and the isolation of drugs from natural sources. Subsequent chapters discuss more specialised aspects of medicinal chemistry and outline drug and analogue synthesis, development and production. Each chapter contains self-assessment questions, numerous examples and a wide variety of applications. Building on the success of the first edition, the book has been completely redesigned to create a clearer, more logical presentation of the material. The text has been extensively revised and updated and includes two new chapters on drugs from natural sources, and drug development and production.? Medicinal Chemistry, Second Edition will prove invaluable to students of chemistry, medicinal and pharmaceutical chemistry, pharmacy and pharmacology whose course includes medicinal chemistry units.
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Preface Acknowledgements. Abbreviations. Chapter 1. An Introduction to Drugs, their Action and Discovery. Chapter 2. Drug Structure and Solubility. Chapter 3. Structure-activity and quantitative structures relationships. Chapter 4. Computer aided drug design. Chapter 5. Combinatorial Chemistry. Chapter 6. Drugs from natural sources. Chapter 7. Biological Membranes. Chapter 8. Receptors and Messengers. Chapter 9. Enzymes. Chapter 10. Nucleic Acids. Chapter 11. Pharmacokinetics. Chapter 12. Drug metabolism. Chapter 13. Complexes and chelating agents. Chapter 14. Nitric oxide. Chapter 15. An Introduction to drug and analogue synthesis. Chapter 16. Drug Development and Production. Selective further reading. Answers to Questions. Index.
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