Applied Antisense Oligonucleotide Technology -

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CHEMISTRY, OLD AND NEW. Oligonucleoside Methylphosphonates: Synthesis and Properties (P. Miller). Oligo(Nucleoside Phosphorothioate)s (P. Guga, et al.). Modified Oligodeoxynucleotides as Antisense Therapeutics (P. Seeberger & M. Caruthers). Novel Chemistry (K. Altmann, et al.). OLIGONUCLEOTIDE INTERNALIZATION, MECHANISM OF ACTION, AND NON-SEQUENCE SPECIFICITY. Cellular Uptake and Biodistribution of Oligodeoxynucleotides (B. Hanss, et al.). Use of Cationic Lipid Complexes for Antisense Oligonucleotide Delivery (C. Bennett). Nonantisense Effects of Antisense Oligonucleotides (L. Neckers & K. Iyer). Ribonuclease H-Mediated Antisense Effects of Oligonucleotides and Controls for Antisense Experiments (D. Tidd). SEQUENCE-SPECIFIC INHIBITION OF GENE EXPRESSION. The Development of C-5 Propyne Oligonucleotides as Inhibitors of Gene Function (W. Flanagan & R. Wagner). The Use of Antisense Oligonucleotides to Inhibit Expression of Isozymes of Protein Kinase C (N. Dean, et al.). BCR-ABL as a Target for Antisense Intervention (S. O'Brien & T. Smetsers). The NF-kB Transcription Factor (R. Narayanan). Disruption of the Map Kinase Signaling Pathway Using Antisense Oligonucleotide Inhibitors Targeted to RAS and RAF Kinase (B. Monia). Protein Kinase A-Directed Antisense Blockade of Cancer Growth: Single Gene-Based Therapeutic Approach (Y. Cho-Chung). Use of Antisense Oligonucleotides in the Central Nervous System: Why Such Success? (M. McCarthy). APPLIED ANTISENSE OLIGONUCLEOTIDE THERAPEUTICS. Perturbing Hematopoietic Cell Gene Expression with Oligodeoxynucleotides: Research and Clinical Applications (A. Gewirtz & M. Ratajczak). BCL2 (B. Jansen & B. Brown). Biological Activity of Guanosine Quartet-Forming Oligonucleotides (R. Rando & M. Hogan). OLIGONUCLEOTIDES AS ANTI-HIV AGENTS. Perspectives on Antisense Technology Against HIV (J. Gee, et al.). In Vivo Pharmacokinetics of Oligonucleotides (S. Agrawal). Early Clinical Trails with Gem 91, A Systemic Oligodeoxynucleotide (R. Martin). THERAPEUTIC OLIGONUCLEOTIDE DATA BASE: PHARMACOKINETICS, IMMUNE STIMULATION, AND USE AS ANTIRESTENOTIC AGENTS. Antisense Therapy to Inhibit Angioplasty Restenosis (L. Rabbani & W. Wang). Pharmacokinetics of Oligonucleotides: A Review of Current Knowledge and Issues for the Future (T. Wallace & P. Cossum). Leukocyte Stimulation by Oligodeoxynucleotides (A. Krieg). SELECTED OLIGODEOXYNUCLEOTIDE DEVELOPMENTAL TOPICS: SPLICING AND TRIPLEXES. Modification of Alternative Splicing of Pre-mRNA by Antisense Oligonucleotides (R. Kole). Gene-Targeted Triple-Helix-Forming Oligonucleotides (F. Svinarchuk & C. Malvy). Triplex-Forming Oligonucleotides for Genetic Manipulation: An Alternative View (A. Faruqi & P. Glazer). A REVIEW OF RIBOZYME TECHNOLOGY. Therapeutic Ribozymes: Principles, Applications, and Problems (J. Rossi). Index.