Structure and Function of the Neural Cell Adhesion Molecule NCAM -

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Résumé :
Structure and Ligands of NCAM.- Structural Biology of NCAM.- Extracellular Protein Interactions Mediated by the Neural Cell Adhesion Molecule, NCAM: Heterophilic Interactions Between NCAM and Cell Adhesion Molecules, Extracellular Matrix Proteins, and Viruses.- Intracelluar Ligands of NCAM.- NCAM and the FGF-Receptor.- The Role of ATP in the Regulation of NCAM Function.- NCAM and Polysialic Acid.- Polysialylation of NCAM.- Structural Basis for the Polysialylation of the Neural Cell Adhesion Molecule.- The Role of PSA-NCAM in Adult Neurogenesis.- Use of PSA-NCAM in Repair of the Central Nervous System.- NCAM-mediated Signal Transduction.- Signaling Pathways Involved in NCAM-Induced Neurite Outgrowth.- Role of the Growth-Associated Protein GAP-43 in NCAM-Mediated Neurite Outgrowth.- The Neural Cell Adhesion Molecule NCAM and Lipid Rafts.- The Neural Cell Adhesion Molecule and Epidermal Growth Factor Receptor: Signaling Crosstalk.- NCAM Metabolism.- Biosynthesis of NCAM.- Soluble NCAM.- NCAM, Synapses, Emotions, and Memory.- Role of NCAM in Spine Dynamics and Synaptogenesis.- NCAM in Long-Term Potentiation and Learning.- Role of NCAM in Emotion and Learning.- NCAM in Disease.- NCAM in Neuropsychiatric and Neurodegenerative Disorders.- Neural Cell Adhesion Molecule in Cancer: Expression and Mechanisms.- Pharmacology of NCAM: NCAM Mimetics.- NCAM Mimetic Peptides: An Update.- Synthetic NCAM-Derived Ligands of the Fibroblast Growth Factor Receptor.- Dendritic Spine and Synapse Morphological Alterations Induced by a Neural Cell Adhesion Molecule Mimetic.- Orthologs and Paralogs of NCAM.- Fasciclin II: The NCAM Ortholog in Drosophila melanogaster.- The Neural Cell Adhesion Molecule NCAM2/OCAM/RNCAM, a Close Relative to NCAM.- Conclusion.- Honoring Dr. Elisabeth Bock....

Sommaire:
Preface Structural Biology of NCAM
Vladislav Soroka, Christina Kasper and Flemming M. Poulsen
Extracellular Protein Interactions Mediated by NCAM: Heterophilic Interactions between NCAM and Cell Adhesion Molecules, Extracellular Matrix Proteins, and Viruses
Janne Nielsen, Nikolaj Kulahin and Peter S. Walmod
Intracellular Ligands of NCAM
Bettina B?ttner and R?diger Horstkorte
NCAM and the FGF receptor
Vladislav V. Kiselyov
The Role of ATP in the Regulation of NCAM Function
Martin V. H?bschmann and Galina Skladchikova
Polysialylation of NCAM
Herbert Hildebrandt, Martina M?hlenhoff and Rita Gerardy-Schahn
Structural Basis for the Polysialylation of NCAM
Karen J. Colley
The Role of PSA-NCAM in Adult Neurogenesis
Eduardo Gascon, Laszlo Vutskits and Jozsef Zoltan Kiss
Use of PSA-NCAM in Repair of the Central Nervous System
Abderrahman El Maarouf and Urs Rutishauser
Signaling Pathways Involved in NCAM-induced Neurite Outgrowth
Dorte Kornerup Ditlevsen and Kateryna Kolkova
Role of Growth-Associated Protein GAP-43 in NCAM-mediated Neurite Outgrowth
Irina Korshunova, Mark Mosevitsky
NCAM and Lipid Rafts
Gro Klitgaard Povlsen and Dorte Kornerup Ditlevsen
NCAM and Epidermal Growth Factor Receptor: Signaling Crosstalk
Gro Klitgaard Povlsen
Biosynthesis of NCAM
Kateryna Kolkova
Soluble NCAM
Thomas Secher
Role of NCAM in Spine Dynamics and Synaptogenesis
Dominique Muller, Pablo Mendez, Mathias De Roo, Paul Klauser, S. Steen and Lorenzo Poglia
NCAM in Long-termPotentiation and Learning
Barbara P. Hartz and Lars Christian B. R?nn
Role of NCAM in Emotion and Learning
Lisa Conboy, Reto Bisaz, Kamila Markram and Carmen Sandi
NCAM in Neuropsychiatric and Neurodegenerative Disorders
Leann H. Brennaman and Patricia F. Maness
NCAM in Cancer: Expression and Mechanisms
Silvia Zecchini and Ugo Cavallaro
NCAM Mimetic Peptides: An Update
Vladimir Berezin and Elisabeth Bock
Synthetic NCAM-derived Ligands of the FGF receptor
Stine Maria Hansen, Shizhong Li, Elisabeth Bock and Vladimir Berezin
Dendritic Spine and Synapse Morphological Alterations Induced by an NCAM Mimetic
Michael Stewart, Victor Popov, Nilolai Medvedev, Paul Gabbott, Nicola Corbett, Igor Kraev and Heather Davies
Fasciclin II: The NCAM Ortholog in Drosophila melanogaster
Lars V. Kristiansen and Michael Hortsch
The Neural Cell Adhesion Molecule NCAM2/OCAM/RNCAM: A Close Relative of NCAM
Nikolaj Kulahin and Peter S. Walmod
Honoring Dr. Elisabeth Bock
Vladimir Berezin