Hemophilia - Eckdahl, Todd

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Résumé :
Hemophilia is a genetic disease that impairs the normal process of blood clotting and results in uncontrolled external and internal bleeding. The reader of this book will learn how a diagnosis of hemophilia is made by blood clot?ting tests and measurements of clotting factor levels in blood. The book describes how hemophilia A and B are caused by mutations in genes that encode clotting factor VIII and clotting factor IX, respectively, both of which are carried on the X chromosome. As a result, almost all children born with hemophilia A and B are boys. Hemophilia C is caused by mutations in the clotting factor XI gene on chromosome 4, and occurs in males and females with equal frequency. The author details the use of factor replacement therapy to treat hemophilia, and evaluates the prospects for curing hemophilia through gene therapy and genome editing.

Biographie:
Dr. Todd T. Eckdahl earned a BS in chemistry from the University Minnesota, Duluth, and a PhD in molecular genetics from Purdue University. He is currently professor of biology at Missouri Western State University, where he teaches genetics and conducts research in collaboration with undergraduate students that is supported by the National Science Foundation. Dr. Eckdahl has published over 40 articles in professional journals that contribute to molecular genetics and synthetic biology research and to undergraduate science education. He is a member of the Missouri Academy of Science, the Genome Consortium for Active Teaching, and Genomics Education Partnership. Dr. Eckdahl has been recognized for his teaching and research with the Missouri Governor's Award for Excellence in Teaching, the Missouri Western Board of Governors Distinguished Professor Award, the James V. Mehl Outstanding Faculty Scholarship Award, the Missouri Western Alumni Association Distinguished Faculty Award, and the Jesse Lee Meyers Excellence in Teaching Award....