Cancer Clinical Trials -

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Sommaire:
Scientific Fundamentals.- The Crooked Path Toward the Objectivation of Therapeutic Experience.- Randomised Trials: The Case for Science in Medicine.- A Critical Assessment of Approaches to Improving the Efficiency of Cancer Clinical Trials.- Statistical Standards for Protocols and Protocol Deviations.- The Design of Cancer Prevention Trials.- Heterogeneous Treatment Effects.- Strategies for Subgroup Analysis in Clinical Trials.- Statistical Tools for Subset Analysis in Clinical Trials.- Competing Risks, Interactions and Crossing Hazards.- Significance Testing in the Comparison of Survival Curves from Clinical Trials of Cancer Treatment.- Estimating the Magnitude of Benefits from Adjuvant Therapy.- Treatment by Protocol: Assessment of Gains and Losses.- On Combining Information: Historical Controls, Overviews, and Comprehensive Cohort Studies.- The Use of Data Bases and Historical Controls in Treatment Comparisons.- Limitations and Advantages of Meta-analysis in Clinical Trials.- Overview of Adjuvant Radiotherapy for Breast Cancer.- Overview of Randomized Trials of Postoperative Adjuvant Radiotherapy in Breast Cancer.- Combining Randomized and Nonrandomized Patients in the Statistical Analysis of Clinical Trials.- The Comprehensive Cohort Study: The Use of Registry Data to Confirm and Extend a Randomized Trial.- Subjective Opinions and Informed Consent.- Treatment Decisions in Breast Cancer.- Randomization and Follow-up Care of Patients in a Breast Cancer Clinical Trial: Personal Experience.- Alternative Treatments for Small Cancers of the Breast: Motives and Preferences of Patients Having to Choose.- Subjective Theories on Etiology and Treatment of Cancer.- Individual Cases and the Scientific Method-A Conflict? Legal Aspects of Cancer Clinical Trials in the FederalRepublic of Germany.- The Value of Small Clinical Trials.- A Predictive Approach to Selecting the Size of a Clinical Trial, Based on Subjective Clinical Opinion.- Statistical Properties and Use of Sequential Methods in Randomized Clinical Trials when the Response Criterion Is Censored.- Assessment of Quality of Life.- Measurement of Quality of Life in Clinical Trials of Therapy.- A Modular Approach to Quality-of-Life Assessment in Cancer Clinical Trials.- Effects of Breast Conservation on Psychological Morbidity Associated with Diagnosis and Treatment of Early Breast Cancer.- Evaluation of Psychosocial Aspects in a Breast Preservation Trial.