Molecular Diagnostics -

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Résumé :
One of the most notable trends in biomedical science in recent years has been the increasing use of molecular techniques as part of the diagnosis of disease. As such, there is a growing need for students to understand the technological basis of molecular analysis and to have a comprehensive appreciation of their use in diagnosis. Combining coverage of molecular techniques with their application to diagnostic pathology, this book provides students with a thorough and up to date appreciation of the scope of molecular analysis, the principles of the technology used, and thematic diagnostic application. As part of the Fundamentals of Biomedical Science series, the book provides a unique blend of theory and practice, featuring a range of learning features to help students assimilate the information presented quickly and effectively. It will be relevant to undergraduate students on a wide variety of biomedical pathways, cutting across traditional discipline boundaries to provide a unified overview of molecular diagnostics....

Biographie:
Anthony Warford is Emeritus Fellow in the Department of Biomedical Sciences at the University of Westminster, Fellow of the Institute of Biomedical Sciences, and Chartered Scientist. He is the primary author of two scientific papers on tissue microarray, two reviews on in situ hybridisation, and a book chapter on same subject, as well as being a co-author of many other papers. He has lectured internationally on immunohistochemistry and in situ hybridisation. Nad?ge Presneau is Senior Lecturer in the Department of Biomedical Sciences at the University of Westminster. She teaches Molecular Pathology and Cancer Genetics/Genomics at undergraduate and postgraduate levels. Her research focuses principally on developing new bioinformatics approaches to identify driver genes involved in breast cancer using high throughput technologies such as Next Generation Sequencing. She is also interested in the development of new diagnostic tools for cancer as well as biobanking and ethics in translational research....

Sommaire:

• Introduction
• 1: Anthony Warford and Sandra Hing: Sample preparation
• 2: Sandra Hing and Anthony Warford: The molecular laboratory
• 3: Anthony Warford and Emanuela V Volpi: Intact sample analysis
• 4: Nad?ge Presneau, Abdul Hye, and Nicholas Ashton: Homogenate sample analysis
• 5: Nad?ge Presneau and Rifat Hamoudi: Sequencing technologies
• 6: Rifat Hamoudi and Anthony Warford: Molecular analysis and interpreting molecular data
• 7: Nad?ge Presneau and Mary Alikian: Recent technical advances in molecular analysis
• 8: Georgina Ryland and Piers Blombery: Haemopoietic diseases 1 - leukaemias
• 9: Mark Catherwood and Ken Mills: Haemopoietic diseases 2 - lymphoproliferative disorders
• 10: Mary Falzon, Elaine Borg, and Alexandra Saetta: Breast cancer
• 11: Manuel Rodriguez-Justo: Epithelial tumours and melanoma
• 12: Fernanda Amary: Mesenchymal tumours
• 13: Claire V.S. Brasted-Pike: Pre-natal and neo-natal testing