DIABETIC PANCREAS 1985/E 2/E - Bruno W. Volk

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Résumé :
Since the publication of the first edition of The Diabetic Pancreas in 1977, much progress has been made in various areas of diabetes research. While only a rela? tively short while ago diabetes was considered a single disease, in more recent years it has become apparent that it is a heterogeneous group of disorders, all of which are characterized by a decreased tolerance of carbohydrates and most of which have a genetic basis, although the genetic types vary. In more recent years, an International Work Group sponsored by the National Diabetes Data Group of the NIH proposed a now generally accepted classification, according to which the insulin-dependent ketosis-prone diabetes, formerly and inappropriately called the juvenile type, is considered a subclass of diabetes, type 1. Because it can occur at any age, it was recommended that the diagnosis based on age be eliminated. The non-insulin-dependent, non-keto sis-prone type of diabetes, which is not secondary to other diseases or conditions, and which was formerly called matu? rity-onset diabetes, was considered a second subclass, type II, because although this form usually develops after age 40, it also occurs in young persons, who do not require insulin or are not ketotic. Although this classification is not entirely agreed upon by all diabetologists, for practical purposes it has been generally accepted and has been utilized by the contributors to this volume.

Sommaire:
1 Historical Review.- 2 Comparative Morphology of Pancreatic Islets in Animals.- 3 Growth Pattern of Pancreatic Islets in Animals.- 4 Histology, Cell Types, and Functional Correlation of Islets of Langerhans.- 5 The PP Cell.- 6 Quantitative Studies of the Islets of Nondiabetic Patients.- 7 Histochemistry and Electron Microscopy of Islets.- 8 Morphology of Membrane Systems in Pancreatic Islets.- 9 Regulation and Role of Intracellular Ca2+ in Insulin Secretion by the ? Cell.- 10 Type II (Idiopathic) Diabetes (Non-Insulin-Dependent).- 11 Pathogenetic Considerations of Type II Diabetes.- 12 Hormonal Diabetes Secondary to Extrapancreatic Endocrinopathies.- 13 Pancreatitis, Pancreatic Lithiasis, and Diabetes Mellitus.- 14 Cancer and Diabetes.- 15 Hemochromatosis and Diabetes.- 16 The Pathology of Type I (Juvenile) Diabetes.- 17 The Islets of Infants of Diabetic Mothers.- 18 Spontaneous Diabetes in Animals.- 19 Chemically and Hormonally Induced Diabetes Mellitus.- 20 Viral Diabetes.- 21 Experimental Insulitis.- 22 Immunology of Islet Cells.- 23 Islet Cell Transplantation.- 24 Endocrine Tumors of the Pancreas.- 25 Islet Cell Tumors and the Ulcerogenic Syndrome.