Transgenic and Mutant Tools to Model Brain Disorders -

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Résumé :
As the presence of genetically modified animal models in research laboratories has multiplied, the role of genetic factors in the pathogenesis of brain disorders has become particularly important. The refinement of molecular genetic methods has continued to broaden our understanding of the genetic factors associated with a variety of disorders. In Transgenic and Mutant Tools to Model Brain Disorders, leading scientists specializing in this field contribute a timely collection of recent advances featuring a vast array of topics in order to contribute to the diverse approaches taken toward the evaluation of genetically modified models in biomedical research. Opening with several chapters covering general aspects of genetically modified animal models, the book then continues with detailed chapters on models of specific human brain disorders, including OCD, Rett Syndrome, anxiety disorders, depression, and schizophrenia. As a volume in the successful Neuromethods? series, the chapters provide authoritative reviews covering the most commonly used approaches in the field. Cutting-edge and concise, Transgenic and Mutant Tools to Model Brain Disorders offers a comprehensive and descriptive overview on a variety of topics in neuroscience and biological psychiatry.

Sommaire:
Part I: General Approaches

1. Mutant and Transgenic Zebrafish in Modeling Neurobehavioral Disorders
Carisa L. Bergner, Rupert J. Egan, Peter C. Hart, Jonathan M. Cachat, Peter R. Canavello, and Allan V. Kalueff

2. Knockout and Mutant Rats
Mareike M?ller, Jocelien Olivier, and Judith Homberg

3. Rat Mutants with Lateralized Rotational Behavior for Studying Disturbances in Cerebral Asymmetries and Their Involvement in Brain Disorders
Wolfgang L?scher

4. GABAA Receptor a1 Subunit (Gabra1) Knockout Mice: Review and New Results
Gui-Lan Ye, Kevin B. Baker, Sara M. Mason, Wandong Zhang, Laura Kirkpatrick, Thomas H. Lanthorn, and Katerina V. Savelieva

5. Basal Ganglia Disorders in Genetic Models and Experimentally-Induced Lesions
Robert Lalonde and Catherine Strazielle

6. Estrogen Deficient Mouse Models in the Study of Brain Injury and Disease
Rachel A. Hill and Wah Chin Boon

Part II: Specific Brain Disorders

7. The Utility of Genetically Modified Animals in Modeling OCD-Spectrum Disorders
Amanda N. Smolinsky, Carisa L. Bergner, Peter C. Hart, Rupert J. Egan, Brett D. Dufour, Justin L. LaPorte, and Allan V. Kalueff

8. Investigating Rett Syndrome through Genetic Mouse Models: Pre-Symptomatic, Clearly Symptomatic Phases, and Innovative Therapeutic Approaches
Bianca De Filippis, Laura Ricceri, and Giovanni Laviola

9. Genetic Animal Models of Anxiety
Rupert J. Egan, Carisa L. Bergner, Peter C. Hart, Justin L. LaPorte, and Allan V. Kalueff

10. Genetic Animal Models of Depression
Peter R. Canavello, Rupert J. Egan, Carisa L. Bergner, Peter C. Hart, Jonathan M. Cachat, and Allan V. Kalueff

11. Environmental Enrichment and Gene-Environment Interactions in Mouse Models of BrainDisorders
Anthony J. Hannan

12. Mutant and Transgenic Tools in Modeling Schizophrenia
Lieve Desbonnet, Katsunori Tomiyama, Noriaki Koshikawa, Colm M. P. O'Tuathaigh, and John L. Waddington