Endocrinology of Cardiovascular Function -

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Résumé :
Endocrinology of Cardiovascular Function is a fitting inauguration to the Endocrine Update Series. The aim of these publications is to provide the clinician with cutting edge, yet succinct, access to the latest advances in endocrinology. Historically, our understanding of hormonal disturbances was restricted to the classical secretory glands and their targets. As Endocrinology of Cardiovascular Function so aptly indicates, endocrinology is no longer constrained by our early physiologic understanding of glandular disorder. Endocrinology of Cardiovascular Function has set the standard of excellence for the future volumes in this series. Shlomo Melmed, M.D. Series Editor, Endocrine Update Growth factors such as IGF-1 play important roles in cardiovascular cell hypertrophy and the response to acute vascular injury. From another perspective, traditional endocrine hormones, such as estrogen, have been found to participate in preventing the development of atherosclerosis in women, acting through novel mechanisms on target vascular cells. Other `endocrine' hormones, such as PTHRP and adrenomedullin, also modulate cardiovascular and renovascular dynamic states, suggesting new roles for these peptides as vasodilators. This multi-authored text is dedicated to highlighting emerging and important new information regarding the endocrinology of the cardiovascular system. Ellis R. Levin, M.D.

Sommaire:
Cardiovascular Consequences of Estrogen Receptor Gene Mutation in Mice and Men.- Sex Steroids and Endothelin.- Effects of Sex Steroids in Vascular Injury.- Angiotensin II, Growth Factors and the Lipoxygenase Pathway.- Angiotensin II, Oxidative Stress, and Nitric Oxide.- AT1 versus AT2 Receptor.- Physiology of Natriuretic Peptides.- Insulin and Insulin-Like Growth Factor I (IGF-I) Effects on Ca2+ and Nitric Oxide in Diabetes.- Protein Glycation and Diabetic Vascular Disease.- Glucose and PKC in Diabetic Vascular Disease.- Endothelin and Cardiovascular Function.- Insulin-Like Growth Factor I and the Heart.- Cardiovascular Biology of the Parathyroid Hormone-Related Proteins.- Adrenomedullin: Vascular Hormone.- Genetic Disorders of the Renin-Angiotensin-Aldsterone System Causing Hypertension.- Mineralocorticoid Biosynthetic Pathways and Hypertension.- Possible Interactions Among Fatty Acids, Other Lipids, and Aldosterone in the Hypertension of Obesity.