Heart Failure - Marín-García, José

. .

Résumé :
Heart Failure (HF) is the final and common pathway of all cardiovascular diseases. Heart Failure: Bench to Bedside helps address a significant need to develop new paradigms and to identify novel therapeutic targets for this pervasive disease. An authoritative contribution to the field, this book provides a detailed description of new findings and emerging methodologies, as well as a critical clinical evaluation of the complex HF syndrome and future therapies. Heart Failure: Bench to Bedside includes a primer on gene profiling and bioenergetics of the normal heart and a discussion of the molecular, genetic, biochemical and cellular techniques critical to understanding HF. Further chapters discuss cardiac remodeling, oxidative stress, and alterations in other organs and systems that are often associated with HF. This book thoughtfully evaluates current and forthcoming diagnostic techniques and therapies, pharmaceutical and pharmacogenomic-based individualized medicine, gene and cell-based therapies, and the search for new frontiers. Heart Failure: Bench to Bedside presents a clear view of up-to-date approaches to clinical diagnosis and treatment, as well as offering insightful critiques of original and creative scientific thoughts on post-genomic HF research.

Sommaire:
Preface Section I Clinical, Physiology and Genetics Changes in Heart Failure 1. Introduction to Heart Failure 2. Cardiac Function in Heart Failure: The Role of Calcium Cycling 3. Gene Profiling of the Failing Heart - Epigenetics Section II Biochemical and Molecular Changes in Heart Failure 4. Bioenergetics and Metabolic Changes in the Failing Heart Section III The Mitochondrial Organelle and the Heart 5. The Multidimensional Role of Mitochondria in Heart Failure Section IV Experimental Models of Heart Failure 6. Animal Models of Heart Failure Section V Signaling, Stress and Cellular Changes in Heart Failure 7. Signaling Cascades in Heart Failure: From Cardiomyocytes Growth and Survival to Mitochondrial Signaling Pathways 8. Cyclic Nucleotides Signaling (Second Messengers) and Control of Myocardial Function: Effects of Heart Failure 9. Calcium Signaling. Receptors, Effectors and other Signaling Pathways 10. Oxidative Stress and Heart Failure 11. Remodeling and Cellular Death in the Failing Heart Section VI Peripheral Changes and Co-morbid Conditions in Heart Failure 12. Heart failure and changes at the periphery: Vascular, Inflammation, Neurohormonal and Renal systems 13. Comorbidities in Heart Failure Section VII Heart Failure in Children 14. Mechanisms and Clinical Recognition and Management of Heart Failure in Infants and Children 15. Mechanical Circulatory Support and Heart Transplantation in Children with Severe Refractory Heart Failure Section VIII Aging and the Failing Heart 16. Basic Mechanisms Mediating Cardiomyopathy and Heart Failing in Aging 17. Heart Failure of Aging. Clinical Considerations Section IX Diagnostic Methodology in Heart Failure 18. Diagnosis of Heart Failure. Evidence-Based Perspective 19. 'Omics' Application in Heart Failure: Novel Diagnostic and Prognostic Markers to Understand Pathophysiology and Finding New Therapies Section X Available and Forthcoming Therapies for Heart Failure 20. Treatment of Chronic Heart Failure 21. GeneTherapy in Heart Failure: Forthcoming Therapies 22. Myocardial Cell-Based Regeneration in Heart Failure