Structural Proteomics -

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Résumé :
Structural genomics is a newly emerging field that has arisen following the successful footsteps of the major sequencing efforts generally bundled under the heading genomics. In Structural Proteomics: High Throughput Methods, readers are provided with a current view of all aspects of the 'pipeline' that takes protein targets to structures and how these have been optimized. This volume includes chapters describing in-depth the individual steps in the Structural Genomics pipeline, as well as overviews of individual Structural Genomics initiatives. Topics include Target Selection for structural genomics, Protein structure modeling, High-throughput cloning, Mass Spectrometry modeling. Structural Proteomics: High Throughput Methods, encourages its readers to access further details on the methodologies in on-line resources as well as in cited literature making it an invaluable resource. Most methods in this important book are as amenable to small laboratories as to large consortia, and do not require major investments in facilities. This essential volume provides insight into the diversity of approaches adopted by different laboratories and proves that 'high throughput' is really the defining characteristic of structural genomics.

Sommaire:
The objective of this volume of Methods in Molecular Biology on Structural Proteomics: High-throughput methods is to provide readers with a current view of all aspects of the 'pipeline' that takes protein targets to structures and how these have been optimised. This is the first book of protocols to cover techniques in a new and emerging field. The volume includes chapters describing, in-depth, the individual steps in the Structural Genomics pipeline, as well as less detailed overviews of individual Structural Genomics initiatives. The readers are encouraged to access further details on the methodologies in on-line resources and in the cited literature. We emphasize that most methods are as amenable to small laboratories as to large consortia, and do not require major investments in facilities. It is hoped that this volume will help smaller laboratories establish some of the high-throughput techniques....