The Pancreatic Beta Cell - Gerald Litwack

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Résumé :
First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press.

The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed.

This volume focuses on the pancreatic beta cell.

Biographie:
Trained in biochemistry at the University of Wisconsin, Madison, Dr. Litwack worked on enzymology and the effects of hormones on enzyme systems. Then he was a Postdoctoral Fellow of the National Foundation for Infantile Paralysis at the Biochemical Institute of the Sorbonne in Paris. Dr. Litwack's first position was as Assistant Professor of Biochemistry at Rutgers University in 1954. Six years later, he joined the University of Pennsylvania as associate professor and four years later went to the Fels Institute for Cancer Research and Molecular Biology, as full professor, eventually becoming Deputy Director of the Institute. In 1991, he accepted the Chair of Pharmacology at Thomas Jefferson University where he is also Deputy Director of the Jefferson Cancer Institute and Associate Director for Basic Science in the Jefferson Cancer Center. Dr. Litwack's work has been in the area of mechanisms of steroid receptor action involving especially the glucocorticoid and mineralocorticoid receptors, immunophi.

Sommaire:

1. Metabolic Regulation of Insulin SecretionKevin Keane and Philip Newsholme
2. Proinsulin Entry and Transit through the Endoplasmic Reticulum in Pancreatic Beta CellsMing Liu, Jordan Wright, Huan Guo, Yi Xiong and Peter Arvan
3. Metabolism-Secretion Coupling and Mitochondrial Calcium Activities in Clonal Pancreatic Beta-CellsLukas N. Groschner, Muhammad Rizwan Alam and Wolfgang F. Graier
4. Metabolic Syndrome and Ionic Channels in Pancreatic Beta-CellsMarcia Hiriart, Myrian Velasco, Carlos Larqu? and Carlos Manlio Diaz-Garcia
5. The Beta Cell ImmunopeptidomeNadine L. Dudek and Anthony W. Purcell
6. Autophagy and Pancreatic Beta CellsSimona Mazza and Tania Maffucci
7. The Somatostatin Receptor in Human Pancreatic ?-CellsMatthias Braun
8. Modulation of the Pancreatic Islet-Stress Axis as a Novel Potential Therapeutic Target in Diabetes MellitusBarbara Ludwig, Andreas Barthel, Andreas Reichel, Norman L. Block, Stefan Ludwig, Andrew V. Schally and Stefan R. Bornstein
9. Regenerative Medicine for Diabetes: Differentiation of Human Pluripotent Stem Cells into Functional ? Cells in Vitro and their Proposed Journey to Clinical TranslationBipasha Bose, Kishore Reddy Katikireddy and Sudheer Shenoy
10. The Calcium-Sensing Receptor and ?-Cell FunctionPaul E. Squires, Peter M. Jones, Mustafa Y.G. Younis and Claire E. Hills
11. Cellular Inhibitor of Apoptosis Protein-1 and Survival of Beta Cells Undergoing Endoplasmic Reticulum StressPu Xia and Yanfei Qi
12. ?-Cell Responses to Nitric OxideKatarzyna A. Broniowska, Bryndon J. Oleson and John A. Corbett
13. Activated Protein C and its Potential Applications in prevention of islet ? Cell Damage and DiabetesMeilang Xue and Christopher J. Jackson
14. Zinc and its Transporters, Pancreatic ?-Cells, and Insulin MetabolismLiping Huang
15. The NOTCH Pathway in ?-Cell Growth and DifferentiationYael Bar and Shimon Efrat
16. Roles of HNF1a and HNF4a in Pancreatic ?-Cells: Lessons from a Monogenic form of Diabetes (MODY)Kazuya Yamagata
17. Role of the Mammalian Target of Rapamycin (mTOR) Complexes in Pancreatic Beta Cell Mass RegulationAlberto Bartolome and Carlos Guill?n