Cascade Biocatalysis - Sergio Riva

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Résumé :
This ready reference presents environmentally friendly and stereoselective methods of modern biocatalysis. The experienced and renowned team of editor have gathered top international authors for this book. They cover such emerging topics as chemoenzymatic methods and multi-step enzymatic reactions, while showing how these novel methods and concepts can be used for practical applications. Multidisciplinary topics, including directed evolution, dynamic kinetic resolution, and continuous-flow methodology are also discussed.

Biographie:
Dr. Sergio Riva is the Director of the Institute of the Chemistry of Molecular Recognition (ICRM) of the Italian National Council of Research (C.N.R.), where he has been working since 1984, and Professore a Contratto at the University of Modena and Reggio Emilia since 2000. He took his Laurea in Chemistry at Milano University in 1983 and his Diploma di Specialit? in Organic Synthesis at Milano Politecnico in 1989. He spent one year (1987) at M.I.T. (Cambridge, USA) working with Prof. A. Klibanov. In 1993 he was awarded the Ciamician medal by the Organic Chemical Division of the Italian Chemical Society for his research activity in BIOCATALYSIS. His research activity is documented by more than 150 publications reporting on the isolation and characterization of different groups of enzymes (hydrolases, dehydrogenases, oxynitrilases, aldolases, laccases, glycosyltransferases), and on the use of these biocatalysts for the selective modification of different natural compounds (steroids, alkaloids, terpenes, sugars and natural glycosides). Wolf-Dieter Fessner obtained his PhD from the University of Freiburg, following which he carried out postdoctoral research at Harvard University with George Whitesides and at the University of Southern California with George Olah. Since 1998 he has been Full Professor of Organic Chemistry at the Technische UniversitÄt Darmstadt. His primary research interest is focused on the development of practical methods for enzymatic carbon-carbon bond formation and oligosaccharide synthesis, and on the interface between chemical and biological catalysis.

Sommaire:
Directed evolution of ligninolytic oxidoreductases: from functional expression to stabilization New trends in the in situ enzymatic recycling of NAD(P)(H) cofactor Redox Cascade Biotransformations Chemistry and Biochemistry synergies for ß-amino acids production Dynamic kinetic resolution of amino acid thioesters Stereoselective hydrolase-catalyzed processes in continuous-flow mode Perspectives on multi-enzyme processes Nitrile converting enzymes involved in natural and synthetic cascade reactions Mining genomes for nitrilases Kinetic aspects of the in-situ NHase/AMase cascade system of M. imperiale resting cells for nitrile bioconversion Stereoselective hydrolysis of beta substituted nitriles New applications of Transketolase Enzymatic generation of sialoconjugate diversity Methyltransferases in biocatalysis