Patient-Reported Outcomes - Cappelleri, Joseph C.

. .

Résumé :
.

Sommaire:
Introduction Patient-Reported Outcomes in Perspective Patient-Reported Outcomes in Clinical Research Terms and Definitions Measurement Scales Psychometrics vs Clinimetrics Selection of a PRO Questionnaire Development of a Patient-Reported Outcome Population Item Generation Item Wording Cognitive Interviews Validity Content Validity Construct Validity Simulated Example Using SAS: Convergent and Divergent Validity Factors Affecting Response Reliability Intraclass Correlation Coefficient for Continuous Variables ICC Example ICC Simulated Example ICC in Context Bland and Altman Plot for Continuous Variables Simple Kappa and Weighted Kappa Coefficients for Categorical Variables Internal Consistency Reliability: Cronbach's Alpha Coefficient Simulated Example of Cronbach's Alpha Exploratory and Confirmatory Factor Analyses Exploratory Factor Analysis Confirmatory Factor Analysis Causal Indicators vs Effect Indicators Simulated Examples Using SAS: Exploratory Factor Analysis Simulated Examples Using SAS: Confirmatory Factor Analysis Real-Life Examples Item Response Theory Classical Test Theory Revisited Assumptions of IRT Item Characteristic Curves Item Information Item Fit and Person Fit Differential Item Functioning Sample Size Example Example: Rasch Model Implementation Cross-Sectional Analysis Types of PRO Data and Exploratory Methods Comparing Two or More Samples Regression Analysis Longitudinal Analysis Analytic Considerations Repeated Measures Model Random Coefficient Model Real-Life Examples Mediation Models Single Mediator Model Model Invariance Advanced Example Bootstrapping Methodology Implementation Missing Data Study Design to Minimize Missing Data Missing Data Patterns and Mechanisms Approaches for Missing Items within Domains or Measures Approaches for Missing Entire Domains or Entire Questionnaires Sensitivity Analyses Simulated Example Using SAS: Pattern Mixture Models Enriching Interpretation Anchor-Based Approaches Distribution-Based Approaches Multiple Testing Index A Summary and References appear at the end of each chapter.