Receptor-Receptor Interactions - P Michael Conn

. .

Auteur(s) : P Michael Conn

Editeur : Elsevier Science

Langue : Anglais

Parution : 01/10/2013

Format : Moyen, de 350g à 1kg

Nombre de pages : 538

Expédition : 1293

Dimensions : 24.1 x 19.5 x 3.5

ISBN : 0124081436

Résumé :

This new volume of Methods in Cell Biology looks at receptor-receptor interactions, with sections on allosteric and effector interactions, crystallization and modeling, measuring receptor-receptor interactions and oligomerization in individual classes.

With cutting-edge material, this comprehensive collection is intended to guide researchers of receptor-receptor interactions for years to come.

Biographie:
P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center (ONPRC). He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone action in the pituitary and therapeutic approaches that restore misfolded proteins to function. His work has led to drugs that have benefitted humans and animals. He has authored or co-authored over 350 publications in this area and written or edited over 200 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of many professional journals and book series (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). Conn served on the National Board of Medical Examiners, including two years as chairman of the reproduction and endocrinology committee. The work of his laboratory has been recognized with a MERIT award from the NIH, the J.J. Abel Award of the American Society for Pharmacology and Experimental Therapeutics, the Weitzman, Oppenheimer and Ingbar Awards of the Endocrine Society, the National Science Medal of Mexico (the Miguel Aleman Prize) and the Stevenson Award of Canada. He is the recipient of the Oregon State Award for Discovery, the Media Award of the American College of Neuropsychopharmacology and was named a distinguished Alumnus of Baylor College of Medicine in 2012. He is an elected member of the Mexican Institute of Medicine and a fellow of the American Association for the Advancement of Science.

Sommaire:

1. Tyrosine kinase transactivation through direct dimerization
2. Nuclear receptors interaction
3. Lipid rafts and receptor oligomerization
4. Serotonin Type 4 Receptor Dimers
5. Background of methodologies revealing receptor-receptor interactions
6. Oligomerization in class B GPCRs
7. Modeling the structural communication in GPCRs
8. GPCR heteromers and allosteric interactions
9. GPCR heterodimers- asymmetries in signalling
10. Fluorescence correlation spectrascopy and photon counting analysis
11. Fluorescence fluctuation analysis of receptor kinase dimerization
12. Hetero-oligomerization between adenosine A₁ and thromboxane A₂ receptors
13. Transactivation
14. Computational methods for GPCR oligomerization
15. Inverse agonism and oligomerization
16. Oligomerization of sweet and bitter taste receptors
17. Crystallization
18. Analysis of receptor-receptor interaction by combined application of FRET and microscopy
19. Measurement of receptor-receptor oligomerization and arrestin recruitment
20. TCR-TCR interactions
21. Computational methods for receptor oligomerization
22. Implications of peripheral protein oligomerization on biological membranes in live cells
23. Single-molecule imaging
24. EGF receptor oligomerization
25. Receptor oligomerization and biogenesis

26. Constitutive dimerization