Two-Component Signal Transduction - James A. Hoch

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Résumé :
Signal transduction across biological membranes is crucial in enabling cells to recognize and respond to their environment. Over the past ten years, investigators working in prokaryotic molecular biology have identified a number of two-component genetic switches which mediate bacterial signal transduction for essential metabolic and developmental functions and numerous other cellular activities, including regulation of virulence factors in pathogenic bacteria. Edited and written by leading scientists, this book is the first comprehensive reference/text to cover the molecular and cellular biology of a wide variety of two-component signal transduction systems in bacteria. It will prove to be essential for microbiologists working in the areas of gene expression, pathogenesis, and bacterial metabolism, as well as for researchers studying antibiotic resistance and rational drug design.

Sommaire:
Global perspective; Cross regulation and the phosphate regulon; Complex phosphate regulation by sequential switches in B subtilis; Antibiotic biosynthesis in Streptomyces; Genetic switches controlling sporulation in B subtilis; The mechanism of the EnvZ-OmpR response to osmotic stress; Two-component switches in the caulobacter cell cycle; Nitrogen regulation in E coli; Hexosephosphate uptake in E coli; The mechanism of NtrC stimulation of transcription; Mechanism of transcription activation and repression by Spo0A; Control of Salmonella typhimurium virulence; Regulation of Agrobacterium tumifaciens virulence; Control of nitrogen fixation; The nitrate reductase system of E coli; Degradative enzyme synthesis in B subtilis; The vancomycin resistance story; Alginate production in Pseudomonas; Regulation of anaerobiosis in E coli; Regulation of gene transfer in E coli; Communication modules in signal transducing genetic switches; The structure of response regulator modules; The mechanism of the phosphotransfer reaction; Control of chemotaxis; Myxococcus frizzy genes; Conjugal DNA transfer in Bacteriodes