Developmental and Reproductive Toxicology - Ali S. Faqi

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Résumé :
Metabolism and Drug-Drug Interaction in Pregnant Mother/Placenta/Fetus.- Critical Periods of Development in Teratology.- Nonclinical Safety Assessment of Developmental and Reproductive Toxicology: Considerations for Conducting Fertility, Embryo-Fetal Development, and Pre- and Postnatal Developmental Toxicology Studies.- A Developmental and Reproductive Toxicology Program for Chemical Registration.- The Influence of Environmental Contaminants and Lifestyle on Testicular Damage and Male Fertility.- Effects of Chemicals on Mammary Gland Development.- Alternative Methods Used to Assess Potential Embryo-Fetal Developmental Risk of Pharmaceuticals.- Using the Alternative Model C. elegans in Reproductive and Developmental Toxicology Studies.- High-Throughput Screens for Embryonic Stem Cells: Stress-Forced Potency-Stemness Loss Enables Toxicological Assays....

Sommaire:
This meticulous volume covers metabolism and drug-drug interactions during pregnancy, critical periods of developmental toxicology, in vivo and alternative methods to assess potential developmental toxicity for drugs and chemicals, and effects of chemicals on testes and mammary glands. Evaluation of developmental and reproductive toxicology endpoints is an integral part of the safety assessment process for compounds with potential use in women of childbearing age or females that might be exposed during pregnancy as well as men of reproductive potential. The in vivo assessments included here are guideline-driven and are required for submissions for product approval. Written for the Methods in Pharmacology and Toxicology series, this collection includes the kind of detailed implementation advice necessary for success in the lab.?