Iron Chelation Therapy -

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Résumé :
PWithin the last few years, iron research has yielded exciting new insights into the understanding of normal iron homeostasis. Such development, and the evolution of improved strategies of STRONGIron Chelating Therapy/STRONG require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant developments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload./P PThis volume highlights the impact of long term STRONGIron Celating Therapy/STRONG using deferoxamine or the new, but controversial oral iron chelator deferiprone based on experience gained by multicenter trails, with special emphasis on survival, morbidity and drug toxicity; it reviews the development of the new and improved orally effective chelators suitable for clinical use in the near future and examines novel strategies of iron chelating treatment for the control of cell proliferation in malignant disease or malaria. /P

Sommaire:
Pathopysiology of Iron Overload.- 1.Animal Models of Hereditary Iron Transport Disorders.- 2.Mechanism of Iron Toxicity.- 3.Role of Non-Transferrin-Bound Iron in the Pathogenesis of Iron Overload and Toxicity.- 4.Intacellular and Extracellular Labile Iron Pools.- 5.Cardioprotective Effect of Iron Chelators.- Chelation Therapy in Transfulional Siderosis.- 6.Results of Long Term Iron Chelation Treatment with Deferoxamine.- 7.Long Term Deferiprone Chelation Therapy.- Development of New Iron Chelators.- 8.Iron Chelator Chemistry.- 9.Structure-Activity Relationships Among Desazadesferrithiocin Analogues.- 10.ICL670A: Preclinical Profile.- 11.Pyridoxal Isonicotinoyl Hydrazone and Its Analogues.- Novel Strategies in Iron Chelation Treatment.- 12.Therapeutic Potential of Iron Chelators in Cancer Therapy.- 13.Antimalarial Effect of Iron Chelators.