Studies on Experimental Models -

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Résumé :
There is a widespread consensus that use of antioxidants as a therapeutic approach may counteract free radical mediated pathologies. However, the role of antioxidants in normal physiology and redox signaling is still in its infancy. Since oxidative stress is related to various diseases and pathologies, scientists are eager to study the disease in humans, but it is not always ethical to study all the aspects of the disease in humans. Thus, it becomes mandatory to study the disease process and the mechanisms behind it through experimental models which generally involve animals, in vitro/cell culture studies, primates and even humans to a certain extent. Studies on Experimental Models contains data on the experimental models or review of such models of oxidative stress in various diseases. It is structured into six sections, which are as follows: diabetes, cardiovascular, neurology, ocular diseases, toxicology/environmental and in vitro/tissue culture. Each section presents a sketch of models in humans, animals and in vitro methods. Taken together, they comprise a valuable reference for basic and clinical scientists, one aimed at contributing to the advancement of oxidative stress research using appropriate animal models....

Sommaire:
DIABETES?Role of Oxidative Stress and Targeted Antioxidant Therapies in Experimental Models of Diabetic ComplicationsJudy B. de Hann, Karin A. Jandeleit-Dahm, and Terri J. Allen?Experimental Models of Oxidative Stress Related to Cardiovascular Diseases and DiabetesMaria Dolores Mesa, Concepcion M. Aguilera, and Angel Gil?CARDIOVASCULAR?Arachidonic Acid Metabolism and Lipid Peroxidation in Stroke: Alpha-tocotrienol as a Unique Therapeutic AgentCameron Rink, Savita Khanna, and Chandan Sen?Assessment of Oxidative Stress in the Brain of Spontaneously Hypertensive Rat and Stroke-Prone Spontaneously Hypertensive Rat Using by Electron Spin Resonance SpectroscopyFumihiko Yoshino, Kyo Kobayashi, and Masaichi-Chang-il Lee?Small Heat Shock Proteins and Doxorubicin-induced Oxidative Stress in The HeartKarthikeyan Krishnamurthy, Ragu Kanagasabai, Lawrence J. Druhan, and Govindasamy Ilangovan ?Oxidative Stress in Cardiovascular Disease: Potential Biomarkers and Their MeasurementsSubhendu Mukherjee and Dipak K. Das?In vivo Imaging of Antioxidant Effects on NF-kappaB Activity in Reporter MiceIngvild Paur, Harald Carlsen, and Rune Blomhoff??NEUROLOGY?MPTP and Oxidative Stress: It?s Complicated!V. Jackson-Lewis, C. Vives-Bauza, M.A. Tocilescu, R. DeVries, and S. Przedborski?Oxidative Stress in Alzheimer?s Disease: A Critical Appraisal of the Causes and the ConsequencesJaewon chang, Sandra Siedlak, Paula Moreira, Akihiko Nunomura, Rudy J. Castellani, Mark A. Smith, Xiongwei Zhu, George Perry, and Gemma Casadesus?Retinal Disturbances in Patients and Animal Models with Huntington?s, Parkinson?s and Alzheimer?s DiseaseC. Santano M. P?rez de Lara Pintor?Stress Gene Deregulation in Alzheimer Peripheral Blood Mononuclear CellsOlivier C. Maes, Howard M. Chertkow, Eugenia Wang, and Hyman M. Schipper?The Use of Gpx4 Knockout Mice and Transgenic Mice to Study the Roles of Lipid Peroxidation in Diseases and AgingQitao Ran and Hanyu Liang?An Experimental Model of Myocardial and Cerebral Global Ischemia and ReperfusionLars Wiklund and Samar Basu??OCULAR DISEASES?Neovascular Models of the Rabbit Eye Induced by Lipid HydroperoxideTakako Nakanishi, Toshihiko Udea, Kazushi Tamai, Shinichi Iwai, and Donald Armstrong?Purinergic Signaling Involved in the Volume Regulation of Glial Cells in the Rat Retina: Alteration in Experimental DiabetesAndreas Bringmann??TOXICOLOGY / ENVIRONMENTAL ?Helicobacter Pylori-induced Oxidative stress and InflammationHyeyoung Kim and Young-Joon Surh?Experimental Models for Ionizing Radiation ResearchKristin Fabre, William DeGraff, John A. Cook, Murali C. Krishna, and James B. Mitchell?Experimental Models to Study Cigarette Smoke-Induced Oxidative Stress In Vitro and In Vivo in Pre-Clinical Models, and in Smokers and Patients with Airways DiseaseHongwei Yao and Irfan Rahman?Exhaled Breath Condensate Biomarkers of Airway Inflammation and Oxidative Stress in COPDPaolo Montuschi?Induction of Oxidative Stress by Iron/Ascorbate in Isolated Mitochondria and by UV Irradiation in Human SkinIngrid Wiswedel, Wolfgang Augustin, Sven Quist, Harald Gollnick, and Andreas Gardemann?Carbon Tetrachloride Induced Hepatotoxicity: A Classical Model of Lipid Peroxidation and Oxidative StressSamar Basu?Enhanced Urinary Excretion of Lipid Metabolites Following Exposer to Structurally Diverse Toxicants: A Unique Experimental Model for the Assessment of Oxidative StressFrancis C. Lau, Manashi Bagchi, Shirley Zafra-Stone and Debasis Bagchi?Oxidative Stress in Animal Models with Special Reference to Experimental Porcine EndotoxemiaMicl?s Lipcsey, Mats Eriksson, and Samar Basu?Models and Approaches for the Study of Reactive Oxygen Species Generation and Activities in Contracting Sketetal MuscleMalcolm Jackson?Exercise as a Model to Study Interactions Between Oxidative ...