Oncocytic (Hürthle Cell) Thyroid Lesions - Sakr, Mahmoud

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Résumé :

This book provides a comprehensive overview of oncocytic (H?rthle cell) lesions, whether neoplastic or non-neoplastic, with a view to clarifying some uncertainties and helping clinicians reach an accurate diagnosis and choose the best therapeutic options. Many recent studies have highlighted important facts relevant to oncocytic (H?rthle cell) lesions and have proposed several clinical and non-clinical tools that may help in diagnosis and management. Recent molecular studies have shed light on the distinct oncogenic features of oncocytic/H?rthle cell carcinomas, suggesting that they represent a separate pathological entity from both oncocytic/H?rthle cell adenomas and follicular cell carcinomas. However, only a few facts are established, while challenges and debates still encompass most of the spectrum of oncocytic (H?rthle cell) lesions. The volume discusses a wide range of topics, including controversies in nomenclature, origin, and cytology/histology of oncocytic (H?rthle) cells, as well as controversies in oncocytic cell lesion pathogenesis, biological and clinical behavior, diagnosis, and management. Regarding oncocytic (H?rthle cell) neoplasms, this book discusses controversies in pathological classification, clinical presentation, diagnostic work-up, and therapeutic strategies. A special chapter addresses updates in genetic and molecular diagnostics of oncocytic (H?rthle cell) carcinoma. Finally, this book includes a chapter summarizing the recent international guidelines and recommendations related to oncocytic lesions, particularly carcinoma, thus aiding in decision-making and appropriate management. This book is meant for all specialists entrusted with the care of patients suffering from oncocytic thyroid lesions: head and neck surgeons, maxillofacial surgeons, endocrine surgeons, endocrinologists, oncologists, and otolaryngologists....

Biographie:

Prof. Mahmoud Fathi Sakr is a professor of Surgery, Head and Neck and Endocrine Surgery Unit at the Faculty of Medicine, Alexandria University, Egypt. He graduated in 1981 and earned his MS and PhD in Surgery at Alexandria University, Egypt. He completed his fellowship at the University of Pittsburgh, Pennsylvania, USA. He is a fellow of the International College of Surgeons (ICS) and the American College of Surgeons (ACS). His main fields of interest are head and neck and endocrine surgery. Dr. Sakr has published 32 national books and 14 international books, including six published by Springer. He has also published 5 Patient Information Series, a Manual for Clinical Practice, and 118 scientific articles in esteemed journals. He serves on the editorial board of many international journals....

Sommaire:
1. Embryology and Developmental Disorders.- 2. Oncocytic (Hurthle) Cells in Thyroid Disorders.- 3. Oncocytic (Hurthle Cell) Lesions: Controversy of Nomenclature, Origin, and Histology.- 4. Oncocytic (Hurthle Cell) Lesions: Controversy of Pathogenesis, Biology and Clinical Behavior.- 5. Oncocytic (Hurtle Cell) Lesions: Controversy of Oncocytic (Hurthle) Cells in Cytology .- 6. Oncocytic (Hurthle Cell) Lesions: Controversy of Diagnosis &ndash...