Iron in Clinical Practice -

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Résumé :

Learn the tools for addressing a widespread public health issue with this practical guide

Iron deficiency and iron overload are among the most common health conditions encountered in the course of clinical practice, with the potential to produce a range of morbidities and increase overall mortality. However, these conditions are often under-recognized, resulting in unnecessary disease and loss of well-being. There is an urgent need to raise awareness among clinicians of the causes, effects and management of iron imbalance.

Iron in Clinical Practice meets this need with a brisk, practical guide to recognizing and treating both iron deficiency and iron overload in clinical settings. Edited by two Oxford haematologists and leading specialists in iron management, it covers major areas of medicine and surgery impacted by these disorders. The result is an essential resource for both beginning and experienced clinicians.

Iron in Clinical Practice readers will find:

• Introductory chapters outlining the role of iron in the body, its utilization and mechanisms of trafficking and distribution, and how these are impacted by disease.
• Coverage of a range of clinical settings across medicine, surgery and primary care.
• Illustrations, tables, and graphs throughout.

Iron in Clinical Practice is ideal for all health care practitioners of any specialty....

Biographie:

Sue Pavord, MD, is a Consultant Haematologist at Oxford University Hospitals NHS FT, UK, and Associate Senior Lecturer in Medicine at the University of Oxford. She specialises in all aspects of medical haematology and has established services for iron deficiency management in different clinical settings, and has led national guidelines in this area. She is President of the British Society for Haematology 2024-2026.

Noemi Roy, MD, is Consultant Haematologist at Oxford University Hospitals NHS FT, UK, and an Honorary Senior Clinical Lecturer at the University of Oxford. She specialises in red cell disorders and iron overload. She has been a key player in patient and public engagement in the field and is co-founder of the Congenital Anaemia Network....

Sommaire:

List of Contributors xiii

Preface xvii

About the Companion Website xix

Part 1 Introduction to Iron 1

1 An Introduction to Iron in the Body 3
Sue Pavord and Noemi Roy

Introduction 3

Iron in the Body 3

Essential Functions of Iron in the Body 6

Iron Deficiency 6

Iron Overload 6

Bibliography 9

2 Regulation of Iron Trafficking in the Body 11
Megan Teh and Hal Drakesmith

Introduction 11

Hepcidin and Systemic Iron Homeostasis 11

Regulation of Hepcidin 12

Sensing Iron Concentrations 12

Erythropoietic Demand 14

Inflammation 14

Cellular Iron Homeostasis: Ferritin and Transferrin Receptor 14

Assessing Iron Status - How the Markers Used Relate to Underlying Biology 15

Bibliography 16

3 Iron and Immunity 17
Fabiana Busti and Domenico Girelli

Introduction 17

The Battle for Iron and the Concept of 'Nutritional Immunity' 17

Therapeutic Interventions Harnessing Nutritional Immunity 18

Iron Status and Susceptibility to Infections 19

Iron Deficiency and Health of Populations 19

Iron Overload and Risk of Infection 20

Iron Status and Response to Vaccines 20

Bibliography 22

Part 2 Iron Deficiency 23

Part 2a Assessment and Management of Iron Deficiency 25

4 Impact of Iron Deficiency on the Individual 27
Patrick Kyei-Mensah

Introduction 27

Symptoms and Signs of Iron Deficiency 28

Impact of Iron Deficiency on Specific At-risk Groups 28

Pregnancy, Parturition and Lactation 30

Paediatric Population 30

Non-pregnant Premenopausal Women 31

Individuals from Resource-poor Settings 31

Other Clinical Situations Associated with Iron Deficiency 31

Gastrointestinal Bleeding 31

Heart Failure 31

Chronic Obstructive Airway Disease 32

Renal Disease 32

Conclusion 32

Bibliography 32

5 Assessment of Iron Deficiency 33
Hanke L. Matlung and Dorine W. Swinkels

Introduction 33

Definitions 33

Ferritin Thresholds 33

Inflammation and Liver Disease 36

Additional Biomarkers 36

Red Cell Indices 36

Hepcidin Levels 37

Conclusion 38

Bibliography 38

6 Available Treatments for Iron Deficiency 39
Paolo Polzella

Introduction 39

Oral Iron Supplementation 39

Administration of Oral Iron 39

Intravenous Iron Therapy 40

Potential Adverse Effects of Intravenous Iron 41

Individualising Treatment 42

Bibliography 43

Part 2b Causes, Impact, Management and Prevention of Iron Deficiency in Clinical Specialties 45

7 Iron Deficiency in Primary Care 47
David McCartney

Introduction 47

Presentation of Iron Deficiency in Primary Care 47

The Main Causes of Iron Deficiency in Primary Care 48

Pre-menopausal Women 48

Post-menopausal Women and Men 49

Older Adults 49

The Diagnosis of Iron Deficiency in Primary Care 49

Haemoglobin 49

Iron Studies 49

Further Investigations 50

Treatment of Iron Deficiency in Primary Care 50

Dietary Advice and Prevention of Future Iron Deficiency 51

Bibliography 51

8 Iron Deficiency in the Preoperative Patient 53
Caroline R. Evans

Introduction 53

Haemoglobin Thresholds 53

Causes of Iron Deficiency in the Surgical Setting 54

Laboratory Tests 54

Management of Preoperative Iron Deficiency 55

Iron Treatment 55

Po...