Lehninger Biochemistry: Core Concepts and Applications - Aaron A. Hoskins

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Présentation Lehninger Biochemistry: Core Concepts And Applications de Aaron A. Hoskins Format Broché
- Livre

Livre - Aaron A. Hoskins - 01/04/2025 - Broché - Langue : Anglais

Auteur(s) : Aaron A. Hoskins - Alain Viel - Judith Simcox - Michael M. Cox

Editeur : Macmillan Learning

Langue : Anglais

Parution : 01/04/2025

Format : Moyen, de 350g à 1kg

Nombre de pages : 720.0

Dimensions : 2.5 x 2.5 x 2.5

ISBN : 9781319589967

Résumé :
Lehninger Biochemistry: Core Concepts and Applications offers a streamlined, focused exploration of key biochemistry concepts, tailored for students in Chemistry, Biophysics, and other STEM fields. Authored by the creators of the renowned Lehninger Principles of Biochemistry, this text emphasises clear, concise explanations, supported by visually engaging figures and relevant medical applications. It's designed to help students grasp and master the fundamentals of biochemistry, providing a solid foundation for critical thinking and advanced study in the field....

Sommaire:
a Clue to the Origin of Life?

Chapter 10: Biological Information Part 1: DNA and RNA Metabolism

10.1 DNA Replication

DNA Replication Follows a Set of Rules

DNA Polymerases Synthesizes DNA

DNA Replication Requires Many Enzymes and Protein Factors

DNA Replication Occurs in Stages

10.2 DNA Repair and Organization

All Cells Have Multiple DNA Repair Systems

DNA Repair Can Also Occur in the Absence of Replication

DNA Is Organized into Chromatin

10.3 Transcription and RNA Processing

RNA Polymerases Synthesizes RNA

RNA Replication Requires Many Enzymes and Protein Factors

RNA Syntheses Occurs in Stages

Medicines can Target or Be Made by RNA Polymerases

Nearly All Eukaryotic RNAs Must Be Processed

Reverse Transcriptases Produce DNA From RNA

10.4 Regulation of Transcription

Transcription of Specific Genes Requires Regulatory Proteins in Addition to RNA Polymerase

Regulation of Gene Expression in Bacteria

Regulation of Gene Expression in Eukaryotes

Chapter 11: Biological Information Part 2: Protein Metabolism

11.1 The Genetic Code

The Genetic Code Describes How Sets of Nucleic Acids Correspond to Particular Amino Acids

tRNA Anticodons Base Pair with Codons

tRNAs are Charged with Amino Acids for Protein Synthesis

tRNA Charging Requires ATP Hydrolysis

11.2 Structure and Function of Ribosomes

Ribosomes Catalyze Protein Synthesis

Protein Synthesis Occurs in Stages

Translation Factors Interact with the Ribosome During Elongation and Termination

Protein Synthesis by the Ribosomes is Energetically Expensive

11.3 Protein Folding, Modification, and Degradation

Chaperones Help Proteins Fold into Their Native Conformation

Posttranslational Modifications are Critical for the Function of Many Proteins

Protein Degradation is Highly Regulated in Eukaryotes by the Ubiquitin/Proteosome Pathway

11.4 Translational Control

Riboswitches, Small RNAs, and Attenuation Can Control Gene Expression in Bacteria

Eukaryotes Use mRNA Binding Proteins, RNAi, and MicroRNAs to Regulate Protein Production

Chapter 12: Nucleic Acid Technologies

12.1 Defining Genomic Information

The Genome is All of the Nucleic Acid Needed to Support the Life of an Organism

The Polymerase Chain Reaction Provides Targeted Amplification of Genomic Information

DNA Can Be Sequenced

Sanger Sequencing has been Automated

Next-Generation DNA Sequencing Produces Complete Genome Sequences

RNA Can be Sequenced by First Copying the RNA to DNA with Reverse Transcriptase

12.2 Altering Genomic Information

Joining DNA Segments from Different Sources Yields Recombinant DNA Segments Can be Joined Without Using Restriction Enzymes

Cloned DNA Can be Altered to Study Genes and Proteins

CRISPR/Cas Systems Allows Targeted Cleavage or Modification of Genomic Information

12.3 Using Genomic Information

An Altered Genome can Lead to an Altered Transcriptome and Proteome

Genomic Information Can be Used to Identify the Source of Genetic Diseases

Genomic Information Can be Used to Investigate Crimes

Chapter 13: Introduction to Intermediary Metabolism

13.1 What is Metabolism?

Molecules are Metabolized by Anabolic and Catabolic Pathways

Metabolic Pathways can be Converging, Diverging, or Cyclic

13.2 Common Enzyme Reactions in Metabolism

Carbonyls are Important for Makin...

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