From Molecules to Medicines -

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Résumé :
Surface Proteins of Gram-Positive Pathogens: Using Crystallography to Uncover Novel Features in Drug and Vaccine Candidates.- The Rapid Crystallization Strategy for Structure-Based Inhibitor Design.- Fragment-Based Drug Discovery in Academia: Experiences From a Tuberculosis Programme.- Structural Biology Contributions to the Discovery of Drugs to Treat Chronic Myelogenous Leukemia.- Integrating Crystallography into Early Metabolism Studies.- The Foundations of Protein-Ligand Interaction.- Structure-Based Design of Trna-Guanine Transglycosylase Inhibitors.- Progress on New Hepatitis C Virus Targets: NS2 and NS5A.- Protein Structure Modeling.- Structural Biology and Molecular Modeling in the Design of Novel DPP-4 Inhibitors.- Tools to Make 3D Structural Data More Comprehensible: Emovie & Proteopedia.- Structural Studies on Acetylcholinesterase and Paraoxonase Directed Towards Development of Therapeutic Biomolecules for the Treatment of Degenerative Diseases and Protection Against Chemical Threat Agents.- Protein Function Prediction from Structure in Structural Genomics and its Contribution to the Study of Health and Disease.- Crystal Structures of the ?2-Adrenergic Receptor.- Can Structures Lead to Better Drugs? Lessons from Ribosome Research....