Genetic Studies in Model Organisms - Choi, Kwang-Wook

. .

Résumé :
This book reviews key advances and new fundamentals in genetics. The increasing importance of genetic approaches in diverse areas of biology and medical sciences constantly requires in-depth information on genetic discoveries and research strategies for advanced graduate-level students as well as current researchers. This book focuses on genetic studies of various animal model systems and their major contributions to establishing modern genetics. Information covered in this book is mostly based on original research papers that extend from classical to modern genetics and applications. The contents are organized into four parts. Part I introduces fundamental concepts and experimental strategies in classical genetics. Part II discusses molecular genetics with transposons, transgenesis, clonal analysis, and gene editing technologies. Part III emphasizes epigenetic regulation of genome organization and gene expression. Part IV integrates earlier parts with landmark genetic studies on non-coding RNAs in dosage compensation, programmed cell death, growth control related to cancer, and behavioral neurobiology. ...

Biographie:
Kwang-Wook Choi is an active Emeritus Professor in the Department of Biological Sciences at the Korea Advanced Institute of Science and Technology (KAIST). He has BS in microbial genetics from Seoul National University and PhD in Biochemistry from Princeton University, where he learned Drosophila neurogenetics from Chip Quinn. As a postdoctoral fellow, he studied eye development in Drosophila with Seymour Benzer at Caltech. He joined the faculty in the Department of Molecular and Cellular Biology at Baylor College of Medicine. After 14 years at Baylor, he returned to Korea as Chair of the Bio-Department at KAIST. Over 30 years, his research area has covered a broad range of cell and developmental biology in Drosophila. His work has contributed to understanding the molecular genetic basis of pattern formation, cell polarity, and cell fate specification in the developing eye and various organs. Using Drosophila as a model organism for human genetic diseases, he extended his studies todissecting genetic pathways for growth control genes. He received the Michael DeBakey Award for Excellence in Research at Baylor. He served as Chair of the Asia-Pacific Drosophila Board and organized the Asia-Pacific Drosophila Research Conference in Seoul to promote interactions among international Drosophila communities....

Sommaire:
Part I. Mendel, Genetic Models, and Mutations.- Chapter 1. Mendel's Principles of Inheritance and Chromosome Theory.- Chapter 2. Genetic Model Organisms.- Chapter 3. Recombination and Chromosomal Rearrangements.- Chapter 4. Loss-of-Function Mutagenesis in Forward Genetics.- Part II. Transposons, Transgenesis, Gene Editing, and Genetic Mosaics.- Chapter 5. Non-Mendelian Genetics: Transposable elements (I).- Chapter 6. Transposable Elements II: Insertional Mutagenesis.- Chapter 7. Gain-of-Function and Gene Silencing.- Chapter 8. Genetic Interaction, Epistasis, Modifiers.- Chapter 9. Targeted Mutagenesis.- Chapter 10. Transgenesis in Clonal Analysis.- Part III. Epigenetics, Genome Organization, and piRNA.- Chapter 11. Epigenetic Control of Gene Expression.- Chapter 12. Chromosomal Interaction in Chromatin Organization.- Chapter 13. Piwi and piRNA in Germline and Epigenetic Regulation.- Part IV. Applications of Genetic Analysis.- Chapter 14. Genetic Control of Dosage Compensation.- Chapter 15. Genetics of Programmed Cell Death.- Chapter 16. Genetics of Growth Control.- Chapter 17. Genetic Studies on Behavior.