Clinical Immuno-Oncology - John E. Niederhuber

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Auteur(s) : John E. Niederhuber

Editeur : Elsevier - Health Sciences Division

Langue : Anglais

Parution : 01/06/2023

Format : Moyen, de 350g à 1kg

Nombre de pages : 336

Expédition : 524

Dimensions : 15.9 x 24.0 x 1.8

ISBN : 9780323877633

Résumé :

1. Development and Structure of the Lymphoid System
2. The Chemistry, Structure, and Function of Immunoglobulins
3. The Role of the Complement System in Cancer Etiology and Management
4. Cancer and the Science of Innate Immunity
5. Tumor Antigenicity and Cancer as Non-Self
6. Tumor Immune Surveillance
7. The Essential Elements of Adaptive Immunity and Their Relevance to Cancer Immunology
8. Cancer-Avoiding Immune Detection
9. Vaccines and Active Immunization Against Cancer
10. The Major Clinical Components of Cancer Immunotherapy (Modulating Cell-Mediated Immune Mechanisms)
11. The Microbiome and Cancer Immunotherapy
12. The Clinical Application of Immuno-Therapeutics
13. The Effect of COVID-19 on Cancer Immunotherapy and Cancer Care

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Biographie:
sentinel LNs

Chapter 2.0 The Chemistry, Structure, and Function of Immunoglobulins

1. immunoglobulin isotypes
2. the structure of immunoglobulins
3. the genetics of immunoglobulin diversity
4. antibody-dependent cellular cytotoxicity
5. heavy-chain C domain and role of glycosylation
6. the development of humanized monoclonals

Chapter 3.0 The Role of the Complement System in Cancer

1. complement system activation pathways (classical, alternative and lectin)
2. the role of complement activation in cancer progression
3. complement regulatory proteins (CRPs) and cancer
4. the role of compliment activation in the tumor microenvironment enhances tumor growth
5. complement-dependent cytotoxicity in immune therapy of cancer
6. formation of the membrane attack complex (MAC)
7. potential application of anti-complement cancer therapies (C3aR/C5aR/IL-10 pathway)

Chapter 4.0 Cancer as Non-Self

4.1 primary generator of tumor-specific transplantation type antigens

4.2 character of non-self, tumor associated antigens

4.3 immune surveillance - innate immunity

4.4 distinguishing between self and non-self

4.5 toll-like receptors (TLRs)...

Sommaire:
afferent lymph cellular components

1. role of the gut microbiome in immune system development
2. specific functions related to the spread of cancer
3. cancer-induced lymphangiogeneis...